Solute | TMS Resource Portal

Welcome to TMS Solutions' resource portal, Solute, where you will find the latest informative articles about mental health, neuromodulation techniques, and TMS.

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Sep 26, 2022 1:39:00 PM

Different Modalities of Transcranial Magnetic Stimulation to Manage Schizophrenia

SOURCE: The Primary Care Companion to CNS Disorders. 24(4), 2022 Aug 25.

AUTHORS: Soltani E; Bateni H; Shad MU

OBJECTIVE: To analyze all current literature related to different transcranial magnetic stimulation (TMS) modalities in the management of schizophrenia symptoms and compare the main controversies in the outcome measures.

DATA SOURCES: A comprehensive search in Ovid MEDLINE, APA PsycINFO, and PubMed was conducted (1996 to present) to identify all articles using the search terms schizophrenia and single pulse TMS, schizophrenia and paired pulse TMS, schizophrenia and repetitive TMS, schizophrenia and deep TMS, and schizophrenia and TBS.

DATA SELECTION: Search results were limited to the English language and human subjects. Unrelated articles were excluded after the initial review. Nineteen studies fulfilled the eligibility criteria. These studies included 531 schizophrenia patients and 283 healthy controls.

RESULTS: While some adverse effects of TMS are reported, the process is generally considered safe. However, discrepancies exist regarding the length of the cortical silent period. The cortical silent period is thought to be mediated by gamma-aminobutyric acid (GABA) receptors and is
considered a useful probe to assess motor cortical inhibition. It is generally believed that patients with schizophrenia present changes in the cortical silent period due to GABA abnormalities. A few physiologic studies utilized TMS to study motor cortical excitability in schizophrenia and reported longer, and some shorter, cortical silent periods compared with healthy controls. Also, some studies reported a shorter cortical silent period for unmedicated versus medicated patients, while others
reported no differences.

CONCLUSION: TMS treatment is commonly reported to improve auditory hallucination in schizophrenia. Advantage of use of deep TMS over repetitive TMS, however, is controversial.

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Sep 13, 2022 4:59:00 PM

A Causal Role for the Human Subthalamic Nucleus in Non-Selective Cortico-Motor Inhibition

SOURCE: Current Biology. 32(17):3785-3791.e3, 2022 Sep 12.

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Sep 4, 2022 5:45:00 PM

Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition

SOURCE: Journal of Visualized Experiments. (186), 2022 Aug 23.

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Feb 24, 2022 5:33:00 PM

Beyond the Cuckoo's Nest: Patient and Public Attitudes about Psychiatric Electroceutical Interventions

Source: Psychiatric Quarterly. 92(4):1425-1438, 2021 12.

Cabrera LY; Gilbert MMC; McCright AM; Achtyes ED; Bluhm R

Recent research emphasizes the role of psychiatric electroceutical
interventions (PEIs), bioelectronic treatments that employ electrical stimulation to affect and modify brain function, to effectively treat psychiatric disorders. We sought to examine attitudes about three PEIs-electroconvulsive therapy, transcranial magnetic stimulation, and deep brain stimulation-among patients with depression and members of the general public. As part of a larger study to assess different stakeholders' attitudes about PEIs, we conducted semi-structured key
informant interviews with 16 individuals living with depression and 16 non-depressive members of the general public. We used a purposive sampling approach to recruit potential participants based on eligibility criteria. We performed qualitative content analysis of interview transcripts. Participants from both groups expressed an overall cautionary attitude towards PEIs, yet there were mixed attitudes in both groups. Patients commonly described electroconvulsive therapy as scary, traumatic, or intense, while members of the general public often referenced the treatment's negative portrayal in One Flew over the Cuckoo's Nest.
Patients and the general public saw transcranial magnetic stimulation as a potentially viable option, but in most cases only if medication was not effective. Deep brain stimulation attitudes were predominantly negative among patients and cautionary among public. The overall cautionary attitudes towards PEIs, together with the technological features and social aspects underlying those attitudes, highlight the need for unbiased education to fill the gaps in knowledge and inform perceptions of those who may benefit from these treatments.

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Apr 23, 2018 10:44:11 AM

61% of Unmedicated Treatment Resistant Depression Patients Who Did Not Respond to Acute TMS Treatment Responded After Four Weeks of Twice Weekly Deep TMS in the Brainsway Pivotal Trial

61% of Unmedicated Treatment Resistant Depression Patients Who Did Not Respond to Acute TMS Treatment Responded After Four Weeks of Twice Weekly Deep TMS in the Brainsway Pivotal Trial 

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