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SOURCE: Clinical Neurophysiology. 140:59-97, 2022 Aug.

SOURCE: European Stroke Journal. Conference: 8th European Stroke Organisation Conference. Lyon France. 7(1 SUPPL) (pp 492), 2022.

SOURCE: Frontiers in Neuroscience. 16 (no pagination), 2022. Article Number:
866245.

SOURCE: European Neuropsychopharmacology. 56:80-88, 2022 03.

Source: Journal of Affective Disorders. 297:386-395, 2022 01 15.

Authors: Diao Y; Geng M; Fu Y; Wang H; Liu C; Gu J; Dong J; Mu J; Liu X; Wang C

Abstract
BACKGROUND: Exploratory eye movements (EEMs) and P300 are often used to facilitate the clinical diagnosis of depression. However, There were few studies using the combination of EEMs and P300 to build a model for detecting depression and predicting a curative effect.

METHODS: Sixty patients were recruited for 2 groups: high frequency repetitive transcranial magnetic stimulation(rTMS) combined with paroxetine group and simple paroxetine group. Clinical efficacy was evaluated by the Hamilton Depression scale-24(HAMD-24), EEMs and P300. The classification model of the auxiliary diagnosis of depression and the prediction model of the two treatments were developed based on a machine learning algorithm.

RESULTS: The classification model with the greatest accuracy for patients with depression and healthy controls was 95.24% (AUC = 0.75, recall = 1.00, precision = 0.95, F1-score = 0.97). The root mean square error (RMSE) of the model for predicting the efficacy of high frequency rTMS combined with paroxetine was 3.54 (MAE [mean absolute error] = 2.56, R2 = -0.53). The RMSE of the model for predicting the efficacy of paroxetine was 4.97 (MAE = 4.00, R2 = -0.91).

CONCLUSION: Based on the machine learning algorithm, P300 and EEMs data
was suitable for modeling to distinguish depression patients and healthy individuals. However, it was not suitable for predicting the efficacy of high frequency rTMS combined with paroxetine or to predict the efficacy of paroxetine.