Solute | TMS Resource Portal

Welcome to TMS Solutions' resource portal, Solute, where you will find the latest informative articles about mental health, neuromodulation techniques, and TMS.

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Nov 1, 2022 1:24:00 PM

A Case Series of Deep Transcranial Magnetic Stimulation Treatment For Patients With Obsessive-Compulsive Disorder in The Tokyo Metropolitan Area

SOURCE: Journal of Clinical Medicine. 11(20) (no pagination), 2022. Article Number: 6133.

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Oct 20, 2022 3:55:00 PM

Do Exposure Therapy Processes Impact the Efficacy of Deep TMS for Obsessive-Compulsive Disorder?

SOURCE: Journal of Obsessive-Compulsive and Related Disorders. 35 (no pagination), 2022. Article Number: 100756.

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Oct 19, 2022 3:50:00 PM

Deep Transcranial Magnetic Stimulation Effects on the Electrophysiological Parameters in Obsessive-Compulsive Disorder

SOURCE: Clinical EEG & Neuroscience: Official Journal of the EEG & Clinical Neuroscience Society (ENCS). 53(6):484-490, 2022 Nov.

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Sep 25, 2022 4:32:00 PM

Design of Optimal Coils for Deep Transcranial Magnetic Stimulation

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:3447-3450, 2022 Jul.

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Sep 14, 2022 1:14:00 PM

Detailed Measurements and Simulations of Electric Field Distribution of Two TMS Coils Cleared for Obsessive Compulsive Disorder in the Brain and in Specific Regions Associated with OCD

SOURCE: PLoS ONE [Electronic Resource]. 17(8):e0263145, 2022.

AUTHORS: Tzirini M; Roth Y; Harmelech T; Zibman S; Pell GS; Kimiskidis VK; Tendler A; Zangen A; Samaras T

ABSTRACT: The FDA cleared deep transcranial magnetic stimulation (Deep TMS) with the H7 coil for obsessive-compulsive disorder (OCD) treatment, following a double-blinded placebo-controlled multicenter trial. Two years later the FDA cleared TMS with the D-B80 coil on the basis of substantial equivalence. In order to investigate the induced electric field characteristics of the two coils, these were placed at the treatment position for OCD over the prefrontal cortex of a head phantom, and the field distribution was measured. Additionally, numerical simulations were performed in eight Population Head Model repository models with two sets of conductivity values and three Virtual Population anatomical head models and their homogeneous versions. The H7 was found to induce significantly higher maximal electric fields (p<0.0001, t = 11.08) and to stimulate two
to five times larger volumes in the brain (p<0.0001, t = 6.71). The rate of decay of electric field with distance is significantly slower for the H7 coil (p < 0.0001, Wilcoxon matched-pairs test). The field at the scalp is 306% of the field at a 3 cm depth with the D-B80, and 155% with the H7 coil. The H7 induces significantly higher intensities in broader volumes within the brain and in specific brain regions known to be implicated in OCD (dorsal anterior cingulate cortex (dACC), dorsolateral prefrontal cortex (dlPFC), inferior frontal gyrus (IFG), orbitofrontal cortex (OFC) and pre-supplementary motor area (pre-SMA)) compared to the D-B80. Significant field >= 80 V/m is induced by the H7 (D-B80) in 15% (1%) of the dACC, 78% (29%) of the pre-SMA, 50% (20%) of the dlPFC, 30% (12%) of the OFC and 15% (1%) of the IFG. Considering the substantial differences between the two coils, the clinical efficacy in OCD should be tested and verified separately for each coil.

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