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Welcome to TMS Solutions' resource portal, Solute, where you will find the latest informative articles about mental health, neuromodulation techniques, and TMS.

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Feb 28, 2022 5:08:00 PM

Prolonged Continuous Theta Burst Stimulation to Demonstrate a Larger Analgesia as Well as Cortical Excitability Changes Dependent on the Context of a Pain Episode

Source: Frontiers in Aging Neuroscience. 13 (no pagination), 2022. Article Number:
Date of Publication: 28 Jan 2022.

Liu Y.; Yu L.; Che X.; Yan M.

A series of neuropathic pain conditions have a prevalence in older adults
potentially associated with declined functioning of the peripheral and/or central nervous system. Neuropathic pain conditions demonstrate defective cortical excitability and intermissions, which raises questions of the impact of pain on cortical excitability changes and when to deliver repetitive transcranial magnetic stimulation (rTMS) to maximize the analgesic effects. Using prolonged continuous theta-burst stimulation (pcTBS), a relatively new rTMS protocol to increase excitability, this study was designed to investigate pcTBS analgesia and cortical
excitability in the context of pain. With capsaicin application, twenty-nine healthy participants received pcTBS or Sham stimulation either in the phase of pain initialization (capsaicin applied) or pain ascending (20 min after capsaicin application). Pain intensity was measured with a visual-analogic scale (VAS). Cortical excitability was assessed by motor-evoked potential (MEP) and cortical silent period (CSP) which evaluates corticospinal excitability and GABAergic intracortical inhibition, respectively. Our data on pain dynamics demonstrated that
pcTBS produced a consistent analgesic effect regardless of the time frame of pcTBS. More importantly, pcTBS delivered at pain initialization induced a larger pain reduction and a higher response rate compared to the stimulation during pain ascending. We further provide novel findings indicating distinct mechanisms of pcTBS analgesia dependent on the context of pain, in which pcTBS delivered at pain initialization was able to reverse depressed MEP, whereby pcTBS during pain ascending was associated with increased CSP. Overall, our data indicate pcTBS to be a potential protocol in pain management that could be delivered before the
initialization of a pain episode to improve rTMS analgesia, potentially through inducing early corticospinal excitability changes that would be suppressed by nociceptive transmission.

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Oct 27, 2021 3:48:00 PM

Pinging the Brain with Transcranial Magnetic Stimulation Reveals Cortical Reactivity in Time and Space.

Source: Brain Stimulation. 14(2):304-315, 2021 Mar-Apr.

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Jun 1, 2021 4:40:00 PM

Light Aerobic Exercise Modulates Executive Function and Cortical Excitability

European Journal of Neuroscience. 51(7):1723-1734, 2020 04.

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Jun 1, 2021 4:37:00 PM

Inhibitory Effect of Apomorphine on Focal and Non-Focal Plasticity in the Human Motor Cortex

Pharmaceutics. 13 (5) (no pagination), 2021. Article Number: 718. Date of Publication: May 2021.

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Aug 16, 2016 2:15:00 PM

Modulation of Cortical Oscillations by Low-Frequency Direct Cortical Stimulation Is State-Dependent


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