SOURCE: Psychiatria Danubina. 34(2):236-244, 2022 Summer.
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Intermittent Theta-Burst Stimulation TMS Increases GABA in the Medial Prefrontal Cortex: A Preliminary Sham-Controlled Magnetic Resonance Spectroscopy Study in Acute Bipolar Depression
Source: Frontiers in Psychiatry. 12 (no pagination), 2021. Article Number: 665402.
Date of Publication: 11 May 2021.
Authors: Diederichs C.; DeMayo M.M.; Cole J.; Yatham L.N.; Harris A.D.; McGirr A.
Abstract
Background: Magnetic resonance spectroscopy (MRS) has been used to identify gamma-aminobutyric acid (GABA) alterations in mood disorders, particularly in the medial prefrontal cortex (mPFC) where decreased concentrations have been associated with anhedonia. In major depressive disorder (MDD), prior work suggests that repetitive transcranial magnetic stimulation (rTMS) increases mPFC GABA concentrations proportional to antidepressant response. To our knowledge, this has not been examined in acute bipolar depression.
