The role of transcranial magnetic stimulation in evaluation of motor cortex excitability in Rett syndrome.




Curated By TMS Solutions on Jan 19, 2017 9:22:00 AM
Curated By TMS Solutions
 
Title:
The role of transcranial magnetic stimulation in evaluation of motor cortex excitability in Rett syndrome.
Authors:
Krajnc N; Zidar J. Institution Krajnc, Natalija. University Medical Centre, Clinical Institute for Clinical Neurophysiology Zaloska 7, 1000 Ljubljana, Slovenia. Electronic address: natalija.krajnc@mf.uni-lj.siZidar, Janez. University Medical Centre, Clinical Institute for Clinical Neurophysiology Zaloska 7, 1000 Ljubljana, Slovenia.
 
Title:
The role of transcranial magnetic stimulation in evaluation of motor
cortex excitability in Rett syndrome.
 
Source:
European Journal of Paediatric Neurology. 20(4):597-603, 2016 Jul.
 
Abstract:
UNLABELLED: Rett syndrome (RTT) is a frequent neurodevelopmental disorder confirmed by clinical criteria and supported by the methyl-CpG-binding protein 2 gene (MECP2) mutation. A short central motor conduction time (CMCT) was reported in transcranial magnetic stimulation (TMS) studies performed in RTT. This was attributed to hyperexcitability of the motor cortex and/or spinal motor neurons, but was not studied further. AIM: We performed TMS in RTT to evaluate motor cortex excitability bdetermining the cortical motor threshold (CMT) and motor cortex inhibition by the cortical silent period (CSP) besides measuring CMCT.
 
METHODS: Single-pulse TMS was performed in 17 Rett patients, diagnosed by clinical criteria and MECP2 mutation testing, and the same number ohealthy controls. The outcome measures were compared between RTT groups with different antiepileptic drugs (AED) and those with and without the MECP2 mutation.
 
RESULTS: CMCT was shorter, but we found elevated CMT and shorter CSP, which suggests decreased excitatory and inhibitory motor cortical function. The outcome was independent of AED and the presence or absence of the MECP2 mutation.
 
INTERPRETATION: Decreased excitatory and inhibitory motor cortical function could explain the short CMCT, with higher stimulus intensities needed to excite pyramidal neurons.
 
Copyright :
2016 European Paediatric Neurology Society.
 
Published by:
Elsevier Ltd. All rights reserved.
 
Publication Type:
Journal Article.

Topic of this Article:

Topics: Multi-channel Transcranial Magnetic Stimulation, Rett Syndrone


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