Structural Brain Changes are Associated with Response of Negative Symptoms to Prefrontal rTMS in Patients with Schizophrenia




Curated By TMS Solutions on Oct 10, 2017 9:07:00 PM
Curated By TMS Solutions

TITLE
Structural Brain Changes are Associated with Response of Negative Symptoms to Prefrontal Repetitive Transcranial Magnetic Stimulation in Patients with Schizophrenia

AUTHORS
Hasan A; Wobrock T; Guse B; Langguth B; Landgrebe M; Eichhammer P; Frank E; Cordes J; Wolwer W; Musso F; Winterer G; Gaebel W; Hajak G; Ohmann C; Verde PE; Rietschel M; Ahmed R; Honer WG; Dechent P; Malchow B; Castro MFU; Dwyer D; Cabral C; Kreuzer PM; Poeppl TB; Schneider-Axmann T; Falkai P; Koutsouleris N.

SOURCE
Molecular Psychiatry. 22(6):857-864, 2017 Jun.

ABSTRACT
Impaired neural plasticity may be a core pathophysiological process underlying the symptomatology of schizophrenia. Plasticity-enhancing interventions, including repetitive transcranial magnetic stimulation (rTMS), may improve difficult-to-treat symptoms; however, efficacy in large clinical trials appears limited. The high variability of rTMS-related treatment response may be related to a comparably large variation in the ability to generate plastic neural changes. The aim of the present study was to determine whether negative symptom improvement in schizophrenia patients receiving rTMS to the left dorsolateral prefrontal cortex (DLPFC) was related to rTMS-related brain volume changes. A total of 73 schizophrenia patients with predominant negative symptoms were randomized to an active (n=34) or sham (n=39) 10-Hz rTMS intervention applied 5 days per week for 3 weeks to the left DLPFC. Local brain volume changes measured by deformation-based morphometry were correlated with changes in negative symptom severity using a repeated-measures analysis of covariance design. Volume gains in the left hippocampal, parahippocampal and precuneal cortices predicted negative symptom improvement in the active rTMS group (all r-0.441, all P0.009), but not the sham rTMS group (all r0.211, all P0.198). Further analyses comparing negative symptom responders (20% improvement) and non-responders supported the primary analysis, again only in the active rTMS group (F(9, 207)=2.72, P=0.005, partial eta 2=0.106). Heterogeneity in clinical response of negative symptoms in schizophrenia to prefrontal high-frequency rTMS may be related to variability in capacity for structural plasticity, particularly in the left hippocampal region and the precuneus.

Topic of this Article:

Topics: 1- Brain Stimulation Journal Index, Tinnitus, Schizophrenia, rTMS, Rehab, PTSD


Posts by Topic

Subscribe to Solute Email Updates