Simulation of Transcranial Magnetic Stimulation in Head Model with Morphologically-Realistic Cortical Neurons




Curated By TMS Solutions on Jun 15, 2020 4:18:00 PM
Curated By TMS Solutions

TITLE
Simulation of Transcranial Magnetic Stimulation in Head Model with Morphologically-Realistic Cortical Neurons

SOURCE
Brain Stimulation. 13(1):175-189, 2020 Jan - Feb.

AUTHORS
Aberra AS; Wang B; Grill WM; Peterchev AV.

BACKGROUND
Transcranial magnetic stimulation (TMS) enables non-invasive modulation of brain activity with both clinical and research applications, but fundamental questions remain about the neural types and elements TMS activates and how stimulation parameters affect the neural response.

OBJECTIVE
To develop a multi-scale computational model to quantify the effect of TMS parameters on the direct response of individual neurons.

METHODS
We integrated morphologically-realistic neuronal models with TMS-induced electric fields computed in a finite element model of a human head to quantify the cortical response to TMS with several combinations of pulse waveforms and current directions.

RESULTS
TMS activated with lowest intensity intracortical axonal terminations in the superficial gyral crown and lip regions. Layer 5 pyramidal cells had the lowest thresholds, but layer 2/3 pyramidal cells and inhibitory basket cells were also activated at most intensities. Direct activation of layers 1 and 6 was unlikely. Neural activation was largely driven by the field magnitude, rather than the field component normal to the cortical surface. Varying the induced current direction caused a waveform-dependent shift in the activation site and provided a potential mechanism for experimentally observed differences in thresholds and latencies of muscle responses.

CONCLUSIONS
This biophysically-based simulation provides a novel method to elucidate mechanisms and inform parameter selection of TMS and other cortical stimulation modalities. It also serves as a foundation for more detailed network models of the response to TMS, which may include endogenous activity, synaptic connectivity, inputs from intrinsic and extrinsic axonal projections, and corticofugal axons in white matter. Copyright © 2019 Elsevier Inc. All rights reserved. Publication Type Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S..

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Topics: Mechanism of Action


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