TITLE
Repetitive Transcranial Magnetic Stimulation Improves Cognitive Function of Alzheimer’s Disease Patients

AUTHORS
Zhao J; Li Z; Cong Y; Zhang J; Tan M; Zhang H; Geng N; Li M; Yu W; Shan P. Institution Zhao, Junwu. Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, China. Zhao, Junwu. Department of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China. Li, Zhenguang. Department of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China. Cong, Yannan. Department of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China. Zhang, Jinbiao. Department of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China. Tan, Ming. Department of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China. Zhang, Haixia. Department of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China. Geng, Na. Department of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China. Li, Mengfan. Department of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China. Yu, Wenwen. Department of Clinical Medicine (Neurology), Weifang Medical University, Weifang, Shandong, China. Shan, Peiyan. Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, China.

SOURCE
Oncotarget. 8(20):33864-33871, 2017 May 16.

ABSTRACT
Repetitive transcranial magnetic stimulation (rTMS) acts as a kind of widely-applied and non-invasive method in the intervention of some neurological disorders. This prospective, randomized, double-blind, placebo-controlled trial investigates the effect of rTMS on 30 cases of Alzheimer’s disease (AD) participants, who were classified into mild and moderate groups. Neuropsychological tests were carried out using the AD Assessment Scale-cognitive subscale (ADAS-cog), Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and World Health Organization University of California-Los Angeles, Auditory Verbal Learning Test (WHO-UCLA AVLT) before, immediately after, and 6 weeks after the intervention. In this work, data from 30 AD patients revealed that there was no obvious interaction effect of time-by-group. The ADAS-cog, MMSE and WHO-UCLA AVLT score in the rTMS group was significantly improved compared with baselines at 6 weeks after treatment (all p<0.05). Meanwhile, MoCA scores were also obviously ameliorated in the mild AD patients with rTMS. Besides, subgroup analysis showed that the effect of rTMS on the memory and language of mild AD patients was superior to those of moderate AD patients. In conclusion, our findings suggested that repetitive transcranial magnetic stimulation improves cognitive function, memory and language level of AD patients, especially in the mild stage of AD. Thus, rTMS can be recommended as a promising adjuvant therapy combined with cholinesterase inhibitors at the mild stage of AD patients.