Authors:
Noda Y; Silverstein WK; Barr MS; Vila-Rodriguez F; Down ar J; Rajji TK; Fitzgerald PB; Mulsant BH; Vigod SN; Daskalakis ZJ; Bl umberger DM. Institution Noda,Y. Temerty Centre for Therapeutic Brain Intervention, C entre for Addiction and Mental Health,Toronto,Ontario,Canada. Silverstein,W K. Temerty Centre for Therapeutic Brain Interventio n, Centre for Addiction and Mental Health,Toronto,Ontario,Canada. Barr,M S. Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health,Toronto,Ontario,Canada. Vila-Rodriguez,F. Non-Invasive Neurostimulation Therapies Laboratory,Department of Psychiatry,Faculty of Medicine,University of British Columbia,Vancouver,British Columbia,Canada. Downar,J. Department of Psychiatry,University of Toronto,Toronto,Ontario,Canada. Rajji,T K. Temerty Centre for Therapeutic Brain Intervention, C entre for Addiction and Mental Health,Toronto,Ontario,Canada. Fitzgerald,P B. Monash Alfred Psychiatry Research Centre,The Alfred and Monash University Central Clinical School,Melbourne,Victoria ,Australia. Mulsant,B H. Department of Psychiatry,University of Toronto,Toronto,Ontario,Canada. Vigod,S N. Department of Psychiatry,University of Toronto,Toronto,Ontario,Canada. Daskalakis,Z J. Temerty Centre for Therapeutic Brain Interventio n, Centre for Addiction and Mental Health,Toronto,Ontario,Canada. Blumberger,D M. Temerty Centre for Therapeutic Brain Intervent ion, Centre for Addiction and Mental Health,Toronto,Ontario,Canada.
Title:
Neurobiological mechanisms of repetitive transcranial magnetic stimu lation of the dorsolateral prefrontal cortex in depression: a systemat ic review. [Review]
Source:
Psychological Medicine. 45(16):3411-32, 2015 Dec.
Abstract
Depression is one of the most prevalent mental illnesses worldwi de and a leading cause of disability, especially in the setting of trea tment resistance. In recent years, repetitive transcranial magnetic stimu lation (rTMS) has emerged as a promising alternative strategy for treatment-resistant depression and its clinical efficacy has been investigated intensively across the world. However, the underly ing neurobiological mechanisms of the antidepressant effect of rTMS are s till not fully understood. This review aims to systematically synthesize the literature on the neurobiological mechanisms of treatment response t o rTMS in patients with depression. Medline (1996-2014), Embase (1 980-2014) and PsycINFO (1806-2014) were searched under set terms. Three autho rs reviewed each article and came to consensus on the inclusion and ex clusion criteria. All eligible studies were reviewed, duplicates were remo ved, and data were extracted individually. Of 1647 articles identified, 66 studies met both inclusion and exclusion criteria. rTMS affects vario us biological factors that can be measured by current biological techniques. Although a number of studies have explored the neurobiological mechanisms o f rTMS, a large variety of rTMS protocols and parameters limits the abilit y to synthesize these findings into a coherent understanding. However, a convergence of findings suggest that rTMS exerts its therapeut ic effects by altering levels of various neurochemicals, electrophysiolo gy as well as blood flow and activity in the brain in a frequency-dependen t manner. More research is needed to delineate the neurobiological mechanisms of the antidepressant effect of rTMS. The incorporation of biological assessments into future rTMS clinical trials will help in this regard.
Publication Type:
Journal Article. Research Support, Non-U.S. Gov’t. Review.
