Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke.




Curated By TMS Solutions on Aug 25, 2016 8:36:00 AM
Curated By TMS Solutions

Authors:

Julkunen P; Kononen M; Maatta S; Tarkka IM; Hiekkala SH; Saisanen L; Vanninen R; Karhu J; Jakala P. Institution Julkunen,Petro. Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland; Department of Applied Physics, Univers ity of Eastern Finland, Kuopio, Finland. Electronic address: petro.julkunen@kuh.fi . Kononen,Mervi. Department of Clinical Neurophysiology, Kuopio Un iversity Hospital, Kuopio, Finland; Department of Clinical Radiology, Ku opio University Hospital, Kuopio, Finland. Ma atta,Sara. Department of Clinical Neurophysiology, Kuopio Universit y Hospital, Kuopio, Finland; Institute of Clinical Medici ne, Clinical Neurophysiology, University of Eastern Finland, Finland. Tarkka,Ina M. Department of Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. Hiekkala,Sinikka H. The Finnish Association of People with Phy sical Disabilities, Validia Rehabilitation, Helsinki, Finland. Saisanen,Laura. Department of Clinical Neurophysiology, Kuopio U niversity Hospital, Kuopio, Finland; Institute of Clinical Medici ne, Clinical Neurophysiology, University of Eastern Finland, Finland. Vanninen,Ritva. Department of Clinical Radiology, Kuopio Universit y Hospital, Kuopio, Finland; Institute of Clinical Medici ne, Clinical Radiology, University of Eastern Finland, Kuopio, Finland. Karhu,Jari. Nexstim Plc, Helsinki, Finland. Jakala,Pekka. Institute of Clinical Medicine, Neurology, Univers ity of Eastern Finland, Kuopio, Finland.

Title:

Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke.

Source: Neuroscience Letters. 617:88-93, 2016 Mar 23.

Abstract: Corticospinal excitability (CSE) is modulated by stroke- induced lesions affecting the brain. This modulation is known to be dependent on the timing of the evaluation, and strongest abnormalities are often f ound in the acute stage. Our study aimed to characterize changes in CSE asymmet ry between the affected and the unaffected hemisphere (AH and UH) during the first month after stroke onset and at 6 month follow-up. N euronavigated transcranial magnetic stimulation (nTMS) was used to assess the CSE of the abductor pollicis brevis (APB) muscle of the hand and tibi alis anterior (TA) muscle of the leg in 16 patients over 5 time-points. AH ex citability recovered significantly during 6 months, whereas interhemis pheric asymmetry remained significant up to 1 month post-stroke in the APB muscle. Greater initial CSE was associated with good motor f unction at 6 months. The motor cortical excitatory recovery initiated wit hin week of the stroke and was most prominent within 1 month after stroke onset. Lesion size correlated with CSE of the UH at 10 days, while over all severity of the symptoms correlated inversely with CSE of the AH. This study demonstrates the quick improvement in the CSE via estimati on of interhemispheric asymmetry; however, the recovery in the asymmetry continues to normalize even after reaching the threshold for normal values n

CSE.Copyright © 2016 Elsevier Ireland Ltd. All right s reserved.

Publication Type Journal Article. Research Support, Non-U.S. Gov't.

Topic of this Article:

Topics: Stroke


Posts by Topic

Subscribe to Solute Email Updates