TITLE
Left Prefrontal Repetitive Transcranial Magnetic Stimulation in a Logopenic Variant of Primary Progressive Aphasia: A Case Report
AUTHORS
Bereau M; Magnin E; Nicolier M; Berthet L; Dariel E; Ferreira S; Sylvestre G; Monnin J; Chopard G; Bouladour H; Vandel P; Haffen E.
SOURCE
European Neurology. 76(1-2):12-8, 2016.
BACKGROUND / AIMS
High frequency repetitive transcranial magnetic stimulation (hf-rTMS) improves language skills in Alzheimer’s disease (AD). We report the use of hf-rTMS in a patient with logopenic primary progressive aphasia (LPPA) due to AD.
METHOD
hf-rTMS was applied to the left dorsolateral prefrontal cortex of a LPPA patient. Cerebral perfusion, neuropsychological and linguistic performances were evaluated before and 1 month after hf-rTMS.
RESULTS
The tolerance was good. Improvements on linguistic (fluency, naming, lesser paraphasia) and cognitive skills (Mini Mental State Examination, verbal memory free recall, speed processing) and cerebral perfusion were observed.
CONCLUSION
hf-rTMS can be used in LPPA patients. A procognitive effect persisting several weeks after stimulation in LPPA patients was suggested and should therefore be evaluated in a clinical trial as an adjunctive therapeutic tool.
