Title:
Intermittent theta burst stimulation over left BA10 enhances virtualreality-based prospective memory in healthy aged subjects.
Authors:
Debarnot U; Crepon B; Orriols E; Abram M; Charron S; Lion S; Roca P; Oppenheim C; Gueguen B; Ergis AM; Baron JC; Piolino P.
Source:
Neurobiology of Aging. 36(8):2360-9, 2015 Aug.
Abstract:
Prospective memory (PM) refers to a complex cognitive ability that underpins the delayed execution of previously formulated intentions. PM performance declines early in normal aging and this process is accentuated in Alzheimer’s disease. The left frontopolar cortex (BA10) has been consistently assigned a major role in PM functioning, but whether it can be noninvasively modulated to enhance PM performance in aged people has not been addressed so far. Here, we investigated the effects of modulatin
gleft BA10 by means of theta burst stimulation (TBS), using either excitatory (intermittent TBS), inhibitory (continuous TBS) or control (vertex) TBS in healthy aged subjects. The behavioral effects were assessed using a reliable and ecological virtual reality PM task that included both event- and time-based retrievals. As compared with vertex stimulation, event-based PM performance significantly improved after excitatory stimulation, whereas inhibitory stimulation had no significant effect. Additionally, and across the different types of stimulation, performance for congruent links between the event-based PM cue and the action to be performed was significantly better as compared with incongruent links. In conclusion, intermittent TBS might provide a relevant interventional strategy to counteract the decline of cognitive functions and memory abilities in normal aging. Copyright © 2015
Elsevier Inc. All rights reserved.
Institution:
Debarnot,Ursula. INSERM UMR S894, Center of Psychiatry and Neurosciences, Sorbonne Paris Cite, University Paris Descartes, Paris, France; Laboratoryof Memory and Cognition, Institute of Psychology, University Paris.
Descartes, Boulogne Billancourt, France; Department of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Neuropsychology of aging (EA 4468), Institute of Psychology, University Paris Descartes, Boulogne Billancourt, France. Electronic address: Ursula.debarnot@gmail.com.
Crepon,Benoit. Department of Clinical Neurophysiology and Epileptology,Sainte-Anne Hospital, Paris, France.
Orriols,Eric. INSERM UMR S894, Center of Psychiatry and Neurosciences, Sorbonne Paris Cite, University Paris Descartes, Paris, France; Laboratory of Memory and Cognition, Institute of Psychology, University Paris Descartes, Boulogne Billancourt, France.
Abram,Maria. INSERM UMR S894, Center of Psychiatry and Neurosciences, Sorbonne Paris Cite, University Paris Descartes, Paris, France; Laboratory of Memory and Cognition, Institute of Psychology, University Paris Descartes, Boulogne Billancourt, France.
Charron,Sylvain. Department of Morphological and Functional Imaging, University Paris Descartes, Center of Psychiatry and Neurosciences, INSERMU894, Paris, France.
Lion,Stephanie. Department of Morphological and Functional Imaging, University Paris Descartes, Center of Psychiatry and Neurosciences, INSERMU894, Paris, France.
Roca,Pauline. Department of Morphological and Functional Imaging,University Paris Descartes, Center of Psychiatry and Neurosciences, INSERMU894, Paris, France.
Oppenheim,Catherine. Department of Morphological and Functional Imaging,University Paris Descartes, Center of Psychiatry and Neurosciences, INSERM U894, Paris, France.
Gueguen,Bernard. Department of Clinical Neurophysiology and Epileptology,Sainte-Anne Hospital, Paris, France.
Ergis,Anne-Marie. Neuropsychology of aging (EA 4468), Institute of Psychology, University Paris Descartes, Boulogne Billancourt, France.
Baron,Jean-Claude. INSERM UMR S894, Center of Psychiatry and Neurosciences, Sorbonne Paris Cite, University Paris Descartes, Paris, France.
Piolino,Pascale. INSERM UMR S894, Center of Psychiatry and Neurosciences, Sorbonne Paris Cite, University Paris Descartes, Paris, France; Laboratory of Memory and Cognition, Institute of Psychology, University ParisDescartes, Boulogne Billancourt, France. Electronic address: pascale.piolino@parisdescartes.fr.
