Authors:
Ma SM; Ni JX; Li XY; Yang LQ; Guo YN; Tang YZ. Institution Ma,Shu-Min. Department of Pain Management, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. Ni,Jia-Xiang. Department of Pain Management, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. Li,Xuan-Ying. Department of Anaesthesiology, University of Hong Kong-Shenzhen Hospital, Guangdong, 518053, China. Yang,Li-Qiang. Department of Pain Management, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. Guo,Yu-Na. Department of Pain Management, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. Tang,Yuan-Zhang. Department of Pain Management, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.
Title:
High-Frequency Repetitive Transcranial Magnetic Stimulation Reduces Pain in Postherpetic Neuralgia. Source Pain Medicine. 16(11):2162-70, 2015 Nov.
Abstract OBJECTIVES: Postherpetic neuralgia (PHN) is one of the most intractable pain disorders, especially in elderly patients. There is evidence that repetitive transcranial magnetic stimulation (rTMS) reduces neuropathic pain; however, its effectiveness for PHN is unknown. This study investigated the efficacy of high-frequency rTMS in patients with PHN. DESIGN: A total of 40 patients were randomly assigned to receive 10 sessions of real or sham rTMS of the primary motor cortex. Each stimulation session consisted of a series of 300 five-second pulses with a frequency of 10 Hz and an interval of 3 seconds between each train, giv ing a total of 1500 pulses per session. The primary outcome was pain intensity measured before stimulation from first intervention (T0) to the final stimulation (T10), and 1 and 3 months after final stimulation (T11 and T12). Other outcomes measured included scores on the short form McGill pain questionnaire, self-rating depression scale, quality of life (QOL), sleep quality, the patient global impression of change, medication regulation, and reported adverse events.
RESULTS: The real rTMS group demonstrated greater reduction of visual analogue scale (VAS) than the sham group at each time point except for T0 (P=0.399) and T1 (P=0.091). Mean VAS reduction in the real rTMS group was 16.89% for duration of disease longer than 6 months. These analgesic effects were associated with long-term improvement in rating-scale items related to QOL. CONCLUSION: The results suggest that rTMS is an effective and safe therapy in patients with PHN. Authors Knijnik LM; Dussan-Sarria JA; Rozisky JR; Torres IL; Brunoni AR; Fregni F; Caumo W. Institution Knijnik,Leonardo M. Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, Brazil. Knijnik,Leonardo M. School of Medicine, Rio Grande do Sul Federal University (UFRGS), Porto Alegre, Brazil. Dussan-Sarria,Jairo A. Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, Brazil. Dussan-Sarria,Jairo A. Post-Graduate Program in Medical Sciences, School of Medicine, UFRGS, Porto Alegre, Brazil. Dussan-Sarria,Jairo A. Pain and Palliative Care Service at HCPA, UFRGS, Porto Alegre, Brazil. Rozisky,Joanna R. Laboratory of Pain and Neuromodulation, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, Brazil. Torres,Iraci L S. Post-Graduate Program in Medical Sciences, School of Medicine, UFRGS, Porto Alegre, Brazil. Torres,Iraci L S. Pharmacology Department, Institute of Basic Health Sciences, UFRGS, Porto Alegre, Brazil. Brunoni,Andre R. Service of Interdisciplinary Neuromodulation, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Braz il. Fregni,Felipe. Spaulding Center of Neuromodulation, Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, U.S.A. Caumo,Wolnei. Laboratory of Pain and Neuromodulation, Hospital de Clin icas de Porto Alegre (HCPA), Porto Alegre, Brazil. Caumo,Wolnei. Pain and Palliative Care Service at HCPA, UFRGS, Porto Alegre, Brazil. Caumo,Wolnei. Department of Surgery, HCPA, UFRGS, Porto Alegre, Brazil. Title Repetitive Transcranial Magnetic Stimulation for Fibromyalgia: Systematic Review and Meta-Analysis. [Review] Source Pain Practice. 16(3):294-304, 2016 Mar. Abstract
BACKGROUND: Fibromyalgia (FM) is a prevalent chronic pain syndrome with few effective therapeutic options available. Repetitive transcranial magnetic stimulation (rTMS) is an emerging therapeutic alternative for this condition; however, results have been mixed.
