Authors:
Chou YH; You H; Wang H; Zhao YP; Hou B; Chen NK; Feng F. Institution Chou,Ying-hui. 1 Brain Imaging and Analysis Center, Duke Uni versity Medical Center , Durham, North Carolina. Chou,Ying-hui. 2 Department of Psychiatry and Behavioral Sciences, Duke University Medical Center , Durham, North Carolina. You,Hui. 3 Department of Radiology, Peking Union Medical College Hospital , Beijing, China . Wang,Han. 4 Department of Neurology, Peking Union Medical Col lege Hospital , Beijing, China . Zhao,Yan-ping. 3 Department of Radiology, Peking Union Medical College Hospital , Beijing, China . Hou,Bo. 3 Department of Radiology, Peking Union Medical College H ospital , Beijing, China . Chen,Nan-kuei. 1 Brain Imaging and Analysis Center, Duke Univer sity Medical Center , Durham, North Carolina. Chen,N an -kuei. 5 Department of Radiology, Duke University Medical Center , Durham, North Carolina. Feng,Feng. 3 Department of Radiology, Peking Union Medical Coll ege Hospital , Beijing, China .
Title:
Effect of Repetitive Transcranial Magnetic Stimulation on fMRI Resting-State Connectivity in Multiple System Atrophy.
Source: Brain Connectivity. 5(7):451-9, 2015 Sep.
Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a noninvas ive neuromodulation technique that has been used to treat neurolog ical and psychiatric conditions. Although results of rTMS interven tion are promising, so far, little is known about the rTMS effect on brain functional networks in clinical populations. In this study, we used a whole-brain connectivity analysis of resting-state functi onal magnetic resonance imaging data to uncover changes in functional con nectivity following rTMS intervention and their association with mot or symptoms in patients with multiple system atrophy (MSA). Patients were randomi zed to active rTMS or sham rTMS groups and completed a 10-session 5-H z rTMS treatment over the left primary motor area. The results showed sign ificant rTMS-related changes in motor symptoms and functional connect ivity. Specifically, (1) significant improvement of motor symptoms was observed in the active rTMS group, but not in the sham rTMS group; and (2) several functional links involving the default mode, cerebellar, and limbic networks exhibited positive changes in functional connectiv ity in the active rTMS group. Moreover, the positive changes in function al connectivity were associated with improvement in motor symptoms for the active rTMS group. The present findings suggest that rTMS may i mprove motor symptoms by modulating functional links connecting to the default mode, cerebellar, and limbic networks, inferring a future t herapeutic candidate for patients with MSA.
Publication Type Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov’t
