Deep TMS Add-On Treatment for Intractable Tourette Syndrome: A Feasibility Study




Curated By TMS Solutions on Jun 13, 2017 12:00:00 AM
Curated By TMS Solutions

TITLE
Deep TMS Add-On Treatment for Intractable Tourette Syndrome: A Feasibility Study

AUTHORS
Bloch Y; Arad S; Levkovitz Y. Institution Bloch, Yuval. a The Emotion-Cognition Research Center, Shalvata Mental Health Care Center, Hod-Hasharon, Israel. Bloch, Yuval. b Child and Adolescent Outpatient Clinic, Shalvata Mental Health Care Center, Hod-Hasharon, Israel. Bloch, Yuval. c Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Arad, Shira. a The Emotion-Cognition Research Center, Shalvata Mental Health Care Center, Hod-Hasharon, Israel. Arad, Shira. c Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Levkovitz, Yechiel. a The Emotion-Cognition Research Center, Shalvata Mental Health Care Center , Hod-Hasharon, Israel. Levkovitz, Yechiel. c Sackler Faculty of Medicine, Tel-Aviv University , Tel-Aviv, Israel.

SOURCE
World Journal of Biological Psychiatry. 17(7):557-61, 2016 Oct.

OBJECTIVES
In a considerable minority of patients who suffer from Tourette syndrome (TS) the disorder persists into adulthood and is associated with severe symptoms and limited therapeutic options. Repetitive transcranial magnetic stimulation (rTMS) to the supplementary motor area (SMA) has shown promising therapeutic results. Deep rTMS is a novel technology that enables deeper non-invasive cortical stimulation. This open-label pilot study is the first to examine the possible role of deep rTMS as add-on treatment for intractable TS.

METHODS
Twelve patients were recruited in order to examine bilateral SMA inhibition via deep TMS using the HBDL coil, as a possible treatment for adult TS treatment-resistant patients. Two patients did not complete the 20-day study protocol.

RESULTS
There were no significant side effects. While tics did not improve among the group as a whole, the subgroup of six patients with combined TS and OCD (obsessive compulsive syndrome) showed significant improvement in tic severity (P = 0.037).

CONCLUSIONS
These findings support the safety of deep rTMS for treating The results also highlight the importance of studying the different TS syndromes separately (e.g., with or without OCD comorbidity) when evaluating deep rTMS protocols for TS patients.

Topic of this Article:

Topics: Tourette's


Posts by Topic

Subscribe to Solute Email Updates