Combining Transcranial Magnetic Stimulation with Functional Magnetic Resonance Imaging for Probing and Modulating Neural Circuits Relevant to Affective Disorders

 

SOURCE
Wiley Interdisciplinary Reviews Cognitive Science. 12(4):e1553, 2021 Jul.

AUTHORS
Oathes DJ; Balderston NL; Kording KP; DeLuisi JA; Perez GM; Medaglia JD; Fan Y; Duprat RJ; Satterthwaite TD; Sheline YI; Linn KA

ABSTRACT
Combining transcranial magnetic stimulation (TMS) with functional magnetic resonance imaging offers an unprecedented tool for studying how brain networks interact in vivo and how repetitive trains of TMS modulate those networks among patients diagnosed with affective disorders. TMS compliments neuroimaging by allowing the interrogation of causal control among brain circuits. Together with TMS, neuroimaging can provide valuable insight into the mechanisms underlying treatment effects and downstream circuit communication. Here we provide a background of the method, review relevant study designs, consider methodological and equipment options, and provide statistical recommendations. We conclude by describing emerging approaches that will extend these tools into exciting new applications.