Solute | TMS Resource Portal

SOURCE: Journal of Psychiatry & Neuroscience. 47(5):E325-E335, 2022 Sep-Oct.

SOURCE: Frontiers in Neurology. 13 (no pagination), 2022. Article Number: 909264.

SOURCE: Frontiers in Neurology. 13 (no pagination), 2022. Article Number: 880161.

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 1055.

SOURCE: Journal of Neurology. 269(10):5487-5496, 2022 Oct.

SOURCE: Frontiers in Human Neuroscience. 16 (no pagination), 2022. Article Number: 960350.

SOURCE: Frontiers in Neuroscience. 16 (no pagination), 2022. Article Number: 885905.

SOURCE: Journal of Neurology. 269(10):5283-5301, 2022 Oct.

SOURCE: Frontiers in Neurology. 13 (no pagination), 2022. Article Number: 940467.

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 1102.

SOURCE: The Primary Care Companion to CNS Disorders. 24(4), 2022 Aug 25.

AUTHORS: Soltani E; Bateni H; Shad MU

ABSTRACT
OBJECTIVE: To analyze all current literature related to different transcranial magnetic stimulation (TMS) modalities in the management of schizophrenia symptoms and compare the main controversies in the outcome measures.

DATA SOURCES: A comprehensive search in Ovid MEDLINE, APA PsycINFO, and PubMed was conducted (1996 to present) to identify all articles using the search terms schizophrenia and single pulse TMS, schizophrenia and paired pulse TMS, schizophrenia and repetitive TMS, schizophrenia and deep TMS, and schizophrenia and TBS.

DATA SELECTION: Search results were limited to the English language and human subjects. Unrelated articles were excluded after the initial review. Nineteen studies fulfilled the eligibility criteria. These studies included 531 schizophrenia patients and 283 healthy controls.

RESULTS: While some adverse effects of TMS are reported, the process is generally considered safe. However, discrepancies exist regarding the length of the cortical silent period. The cortical silent period is thought to be mediated by gamma-aminobutyric acid (GABA) receptors and is
considered a useful probe to assess motor cortical inhibition. It is generally believed that patients with schizophrenia present changes in the cortical silent period due to GABA abnormalities. A few physiologic studies utilized TMS to study motor cortical excitability in schizophrenia and reported longer, and some shorter, cortical silent periods compared with healthy controls. Also, some studies reported a shorter cortical silent period for unmedicated versus medicated patients, while others
reported no differences.

CONCLUSION: TMS treatment is commonly reported to improve auditory hallucination in schizophrenia. Advantage of use of deep TMS over repetitive TMS, however, is controversial.

SOURCE: Obstetrician and Gynaecologist. 24(3) (pp 159-166), 2022.

SOURCE: BJPsych Open. 6(6) (no pagination), 2020. Article Number: e131.

SOURCE: Neuroscience Letters. 788:136859, 2022 09 25.

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:3447-3450, 2022 Jul.

SOURCE: Frontiers in Neurology. 13 (no pagination), 2022. Article Number: 918974.

SOURCE: Seminars in Neurology. 42(3):348-362, 2022 Jun.

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:4383-4386, 2022 Jul.

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 1112.

SOURCE: Experimental Physiology. 107(6):615-630, 2022 06.

SOURCE: Scientific Reports. 12(1):14670, 2022 Aug 29.

AUTHORS: Turrini S; Fiori F; Chiappini E; Santarnecchi E; Romei V; Avenanti A

ABSTRACT: Cortico-cortical paired associative stimulation (ccPAS) is an effective transcranial magnetic stimulation (TMS) method for inducing associative plasticity between interconnected brain areas in humans. Prior ccPAS studies have focused on protocol's aftereffects. Here, we investigated physiological changes induced "online" during ccPAS administration. We tested 109 participants receiving ccPAS over left ventral premotor cortex (PMv) and primary motor cortex (M1) using a standard procedure (90 paired-pulses with 8-ms interstimulus interval, repeated at 0.1 Hz
frequency). On each paired-pulse, we recorded a motor-evoked potential (MEP) to continuously trace the emergence of corticomotor changes. Participant receiving forward-ccPAS (on each pair, a first TMS pulse was administered over PMv, second over M1, i.e., PMv-to-M1) showed a gradual and linear increase in MEP size that did not reach a plateau at the end of the protocol and was greater in participants with low motor threshold. Participants receiving reverse-ccPAS (i.e., M1-to-PMv) showed a trend toward inhibition. Our study highlights the facilitatory and inhibitory modulations that occur during ccPAS administration and suggest that online MEP monitoring could provide insights into the malleability of the motor system and protocol's effectiveness. Our findings open interesting prospects about ccPAS potential optimization in experimental and clinical settings.

SOURCE: Frontiers in Neuroscience. 16 (no pagination), 2022. Article Number: 987455.

SOURCE: Indian Journal of Physiology and Pharmacology. Conference: 64th Annual National Conference of Association of Physiologists and Pharmacologists of India, APPICON 2018. Karnataka India. 62(Supplement 1) (pp 79), 2018.

SOURCE: Experimental Physiology. 107(6):560-561, 2022 06.

SOURCE: Psychophysiology. 59(10):e14069, 2022 Oct.

AUTHORS: Hartmann M; Falconer CJ; Kaelin-Lang A; Muri RM; Mast FW

ABSTRACT: Mental imagery is a powerful capability that engages similar neurophysiological processes that underlie real sensory and motor experiences. Previous studies show that motor cortical excitability can increase during mental imagery of actions. In this study, we focused on possible inhibitory effects of mental imagery on motor functions. We assessed whether imagined arm paralysis modulates motor cortical excitability in healthy participants, as measured by motor evoked potentials (MEPs) of the hand induced by near-threshold transcranial magnetic stimulation (TMS) over the primary motor cortex hand area. We found lower MEP amplitudes during imagined arm paralysis when compared to imagined leg paralysis or baseline stimulation without paralysis imagery. These results show that purely imagined bodily constraints can selectively inhibit basic motor corticospinal functions. The results are discussed in the context of motoric embodiment/disembodiment.

TITLE: Immediate and short-term effects of continuous theta burst transcranial magnetic stimulation over contralesional premotor area on post-stroke spasticity in patients with severe hemiplegia: Study protocol for a randomized controlled trial.

SOURCE: Experimental Neurology. 357:114168, 2022 Nov.

SOURCE: Cancers. 14(2) (no pagination), 2022. Article Number: 340.

SOURCE: Experimental Brain Research. 240(9):2425-2434, 2022 Sep.

SOURCE: Psychophysiology. 59(10):e14078, 2022 Oct.

AUTHORS: Vila-Villar A; Naya-Fernandez M; Madrid A; Madinabeitia-Mancebo E; Robles-Garcia V; Cudeiro J; Arias P

ABSTRACT: Understanding central fatigue during motor activities is important in neuroscience and different medical fields. The central mechanisms of motor fatigue are known in depth for isometric muscle contractions; however, current knowledge about rhythmic movements and central fatigue is rather scarce. In this study, we explored the role of an executive area (left dorsolateral prefrontal cortex [DLPFC]) in fatigue development during rhythmic movement execution, finger tapping (FT) at the maximal rate, and fatigue after effects on the stability of rhythmic patterns. Participants (n = 19) performed six sets of unresisted FT (with a 3 min rest in-between). Each set included four interleaved 30 s repetitions of self-selected (two repetitions) and maximal rate FT (two repetitions)
without rest in-between. Left DLPFC involvement in the task was perturbed by transcranial static magnetic stimulation (tSMS) in two sessions (one real and one sham). Moreover, half of the self-selected FT repetitions were performed concurrently with a demanding cognitive task, the Stroop
test. Compared with sham stimulation, real tSMS stimulation prevented waning in tapping frequency at the maximal rate without affecting perceived levels of fatigue. Participants ' engagement in the Stroop test just prior to maximal FT reduced the movement amplitude during this mode of execution. Movement variability at self-selected rates increased during Stroop execution, especially under fatigue previously induced by maximal FT. Our results indicate cognitive-motor interactions and a prominent role of the prefrontal cortex in fatigue and the motor control of simple repetitive movement patterns. We suggest the need to approach motor fatigue including cognitive perspectives.

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 1064.

SOURCE: Neurology India. 70(4):1448-1453, 2022 Jul-Aug.

SOURCE: Annals of Clinical & Translational Neurology. 9(9):1459-1464, 2022 Sep.

SOURCE: Psychiatry Research. 316:114749, 2022 Oct.

SOURCE: Frontiers in Psychiatry. 13 (no pagination), 2022. Article Number: 924370.

SOURCE: Experimental Brain Research. 240(9):2269-2276, 2022 Sep.

SOURCE: Psychophysiology. 59(10):e14077, 2022 Oct.

AUTHORS: Barhoun P; Fuelscher I; Do M; He JL; Cerins A; Bekkali S; Youssef GJ; Corp D; Major BP; Meaney D; Enticott PG; Hyde C

ABSTRACT: While mentally simulated actions activate similar neural structures to overt movement, the role of the primary motor cortex (PMC) in motor imagery remains disputed. The aim of the study was to use continuous theta burst stimulation (cTBS) to modulate corticospinal activity to investigate the putative role of the PMC in implicit motor imagery in young adults with typical and atypical motor ability. A randomized, double blind, sham-controlled, crossover, offline cTBS protocol was applied to 35 young adults. During three separate sessions, adults with typical and low motor
ability (developmental coordination disorder [DCD]), received active cTBS to the PMC and supplementary motor area (SMA), and sham stimulation to either the PMC or SMA. Following stimulation, participants completed measures of motor imagery (i.e., hand rotation task) and visual imagery (i.e., letter number rotation task). Although active cTBS significantly reduced corticospinal excitability in adults with typical motor ability, neither task performance was altered following active cTBS to the PMC or SMA, compared to performance after sham cTBS. These results did not differ
across motor status (i.e., typical motor ability and DCD). These findings are not consistent with our hypothesis that the PMC (and SMA) is directly involved in motor imagery. Instead, previous motor cortical activation observed during motor imagery may be an epiphenomenon of other neurophysiological processes and/or activity within brain regions involved in motor imagery. This study highlights the need to consider multi-session theta burst stimulation application and its neural effects when probing the putative role of motor cortices in motor imagery.

SOURCE: Journal of Clinical Medicine. 11(17) (no pagination), 2022. Article Number: 5080.

SOURCE: eLife. 11, 2022 09 13.

SOURCE: Journal of Clinical Medicine. 11(4) (no pagination), 2022. Article Number: 993.

SOURCE: PLoS ONE [Electronic Resource]. 17(8):e0263145, 2022.

AUTHORS: Tzirini M; Roth Y; Harmelech T; Zibman S; Pell GS; Kimiskidis VK; Tendler A; Zangen A; Samaras T

ABSTRACT: The FDA cleared deep transcranial magnetic stimulation (Deep TMS) with the H7 coil for obsessive-compulsive disorder (OCD) treatment, following a double-blinded placebo-controlled multicenter trial. Two years later the FDA cleared TMS with the D-B80 coil on the basis of substantial equivalence. In order to investigate the induced electric field characteristics of the two coils, these were placed at the treatment position for OCD over the prefrontal cortex of a head phantom, and the field distribution was measured. Additionally, numerical simulations were performed in eight Population Head Model repository models with two sets of conductivity values and three Virtual Population anatomical head models and their homogeneous versions. The H7 was found to induce significantly higher maximal electric fields (p<0.0001, t = 11.08) and to stimulate two
to five times larger volumes in the brain (p<0.0001, t = 6.71). The rate of decay of electric field with distance is significantly slower for the H7 coil (p < 0.0001, Wilcoxon matched-pairs test). The field at the scalp is 306% of the field at a 3 cm depth with the D-B80, and 155% with the H7 coil. The H7 induces significantly higher intensities in broader volumes within the brain and in specific brain regions known to be implicated in OCD (dorsal anterior cingulate cortex (dACC), dorsolateral prefrontal cortex (dlPFC), inferior frontal gyrus (IFG), orbitofrontal cortex (OFC) and pre-supplementary motor area (pre-SMA)) compared to the D-B80. Significant field >= 80 V/m is induced by the H7 (D-B80) in 15% (1%) of the dACC, 78% (29%) of the pre-SMA, 50% (20%) of the dlPFC, 30% (12%) of the OFC and 15% (1%) of the IFG. Considering the substantial differences between the two coils, the clinical efficacy in OCD should be tested and verified separately for each coil.

SOURCE: Current Biology. 32(17):3785-3791.e3, 2022 Sep 12.

SOURCE: Frontiers in Human Neuroscience. 16 (no pagination), 2022. Article Number: 858465.

SOURCE: International Journal of General Medicine. 15 (pp 7101-7111), 2022.

SOURCE: Brain Research. 1794:148057, 2022 Nov 01.

SOURCE: Neuroscience & Biobehavioral Reviews. 140:104804, 2022 Sep.

AUTHORS: Ding X; Zhang S; Huang W; Zhang S; Zhang L; Hu J; Li J; Ge Q; Wang Y; Ye X; Zhang J

ABSTRACT: In recent years, non-invasive brain stimulation (NIBS) interventions for post-stroke aphasia have received increasing attention, but their effects across different language domains and the influence of targeted locations and moderators remain unclear. Randomized controlled trials (RCTs) on NIBS in patients with post-stroke aphasia were searched. Standardized mean differences (SMDs) for pre-post language changes were pooled in Bayesian network meta-analyses. Moderators were examined using meta-regression. Of the 2105 records identified, 69 RCTs involving 1670 patients were included. Low-frequency (LF)-transcranial magnetic stimulation (rTMS) (SMD
0.84 [0.65,1.03]) was superior to anodal-transcranial direct-current stimulation (a-tDCS) (SMD 0.38 [0.05,0.71]) for global severity. Dual-tDCS was the leading option for naming and repetition. For spontaneous speech, both a-tDCS and dual-tDCS resulted in greater effects than LF-rTMS. As stimulation targets, the right inferior frontal gyrus ranked higher in global severity and spontaneous speech, while the temporoparietal region ranked higher in comprehension. Meta-regression demonstrated that therapeutic effects in the naming domain were moderated by the mean period
of each therapy condition and the first language, while significant associations with age, therapy period, and number of sessions were observed for spontaneous speech. Overall, LF-rTMS is the most prioritized NIBS mode to alleviate global severity. Dual and anodal tDCS outperform rTMS for naming and repetition. The optimal stimulation region varies across different domains.

SOURCE: Neurological Sciences. 43(10):5861-5874, 2022 Oct.

SOURCE: Frontiers in Computational Neuroscience. 16 (no pagination), 2022. Article Number: 943396.

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 1087.

SOURCE: Basic and Clinical Neuroscience. 13(2) (pp 237-246), 2022.

SOURCE: Neuroscience. 499:1-11, 2022 Sep 01.

AUTHORS: Wen X; Chi S; Yu Y; Wang G; Zhang X; Wang Z; Gesang M; Luo B

ABSTRACT: Accumulating evidence indicates that repetitive transcranial magnetic stimulation (rTMS) ameliorates motor symptoms in patients with Parkinson's disease (PD); however, patients' responses to rTMS are different. Here, we aimed to explore neural activity changes in patients with PD exhibiting different responses to high-frequency rTMS treatments using functional magnetic resonance imaging (fMRI). We treated 24 patients with PD using 10-session rTMS (10 Hz) over the supplementary motor area (SMA) for 10 days. Resting-state functional magnetic resonance imaging (rs-fMRI), the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) and other neuropsychological scales were performed at the baseline and endpoint of rTMS treatment. The changes in the fractional amplitude of low-frequency fluctuation (fALFF) were calculated. Significant improvements were observed in motor symptoms, especially in the sub-symptoms of
bradykinesia. All the participants were subsequently stratified into responders and non-responders according to the UPDRS-III reduction. We identified increased fALFF values in the left Crus II of the cerebellar hemisphere and bilateral thalamus as responsive signs to rTMS. Furthermore, the motor response to rTMS over the SMA, measured by the reduction in UPDRS-III and bradykinesia scores, was positively associated with increased fALFF values in the left Crus2 of cerebellar hemisphere,
left lobule VIIB of cerebellar hemisphere, right lobule VI of the cerebellar hemisphere, and the right postcentral gyrus. These findings provide evidence for the involvement of cerebellar activity in the motor response to rTMS treatment.

SOURCE: Biomedizinische Technik. 67(5):333-344, 2022 Oct 26.

SOURCE: Innovations in Clinical Neuroscience. 19(4-6) (pp 11-22), 2022.

SOURCE: Frontiers in Psychiatry. 13 (no pagination), 2022. Article Number: 951595.

SOURCE: Applied Neuropsychology. Adult. 29(6):1413-1424, 2022 Nov-Dec.

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:3939-3942, 2022 Jul.

SOURCE: International Ophthalmology. 42(9):2785-2799, 2022 Sep.

AUTHORS: Tuna AR; Pinto N; Fernandes A; Brardo FM; Pato MV

ABSTRACT
PURPOSE: Theta Burst Stimulation can influence adult neuro-visual response in imbalanced visual pathways, possibly by influencing cortical excitability. Our objective was to compare suppressive imbalance (SI) and visual acuity (VA) after applying repetitive Transcranial Magnetic Stimulation between groups of subjects with normal binocular vision, visual asymmetry, and amblyopia.

METHODS: Thirty-five volunteers between 19 and 51 years of age were split into three groups: 6 volunteers with asymmetric VA (group A); 19 amblyopes (group B); and 10 subjects with normal binocular vision (group C). VA and SI of all groups were evaluated before and after a single session of continuous Theta Burst Stimulation (cTBS) or placebo stimulation over the right occipital cortex.

RESULTS: In both groups A and B, we found a significant VA improvement in the non-dominant eye after cTBS (p = 0.04 and p = 0.01, respectively). In SI evaluation, group A and group B also revealed a significant improvement after the cTBS session (p = 0.03 and p = 0.01, respectively). Finally, in the group of volunteers with normal binocular vision and for placebo groups A and B, there were no significant differences in VA and SI after cTBS.

CONCLUSIONS: Amblyopic and visually asymmetric individuals improved VA and SI of the non-dominant eye after cTBS when compared to baseline and to placebo stimulation. These enhancements were not found in the group of volunteers with normal binocular vision. We can therefore reasonably assume that cTBS may interfere with the visual system of subjects that present some kind of asymmetry, possibly by improving neuronal imbalances.

SOURCE: eNeurologicalSci. 29 (no pagination), 2022. Article Number: 100422.

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:398-401, 2022 Jul.

SOURCE: European Neuropsychopharmacology. 62:49-60, 2022 Sep.

AUTHORS: Meijs H; Prentice A; Lin BD; De Wilde B; Van Hecke J; Niemegeers P; van Eijk K; Luykx JJ; Arns M

ABSTRACT: The treatment of major depressive disorder (MDD) is hampered by low chances of treatment response in each treatment step, which is partly due to a lack of firmly established outcome-predictive biomarkers. Here, we hypothesize that polygenic-informed EEG signatures may help predict antidepressant treatment response. Using a polygenic-informed electroencephalography (EEG) data-driven, data-reduction approach, we identify a brain network in a large cohort (N=1,123), and discover it is sex-specifically (male patients, N=617) associated with polygenic risk score (PRS) of antidepressant response. Subsequently, we demonstrate in three independent datasets the utility of the network in predicting response to antidepressant medication (male, N=232) as well as repetitive transcranial magnetic stimulation (rTMS) and concurrent psychotherapy (male, N=95). This network significantly improves a treatment response prediction model with age and baseline severity data (area under the curve, AUC=0.623 for medicaton; AUC=0.719 for rTMS). A predictive model for MDD patients, aimed at increasing the likelihood of being a responder to antidepressants or rTMS and concurrent psychotherapy based on only this
network, yields a positive predictive value (PPV) of 69% for medication and 77% for rTMS. Finally, blinded out-of-sample validation of the network as predictor for psychotherapy response in another independent dataset (male, N=50) results in a within-subsample response rate of 50% (improvement of 56%). Overall, the findings provide a first proof-of-concept of a combined genetic and neurophysiological approach in the search for clinically-relevant biomarkers in psychiatric disorders, and should encourage researchers to incorporate genetic information, such as PRS, in their search for clinically relevant neuroimaging biomarkers.

SOURCE: Journal of Visualized Experiments. (186), 2022 Aug 23.

SOURCE: Frontiers in Human Neuroscience. 16 (no pagination), 2022. Article Number: 888472.

SOURCE: Psychiatry Research. 316:114750, 2022 Oct.

SOURCE: Frontiers in Neuroscience. 16 (no pagination), 2022. Article Number: 832121.

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 994.

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:2385-2389, 2022 Jul.

SOURCE: Cortex. 154:197-211, 2022 Sep.

AUTHORS: Spaccasassi C; Zanon M; Borgomaneri S; Avenanti A

ABSTRACT: Humans are equipped with an extraordinary ability to understand and imitate actions by mapping the observed movement onto their own cortical motor system. Long-established lines of research have identified two correlates of this motor resonance following action observation: the mu rhythm event-related desynchronization (mu-ERD) recorded through electroencephalography (EEG) and the facilitation of motor evoked potentials (MEPs) induced by transcranial magnetic stimulation (TMS) of the primary motor cortex (M1). Yet, whether mu-ERD and MEP facilitation reflect unique or distinct mechanisms is not conclusive, as prior work did not combine simultaneous TMS-EEG recording with a trial-by-trial analysis of the two markers. To address this issue, here, we used TMS-EEG co-registration while participants observed and executed finger movements. EEG was continuously recorded while single-pulse TMS was administered over the left M1 and MEPs were recorded from the right hand. We found stronger motor cortex recruitment during action execution and observation as shown by mu-ERD. MEPs instead were larger overall during action execution and showed a facilitation specific to the muscles involved in the observed movements. Interestingly, when analyzing these two parameters using a trial-by-trial statistical approach, we did not find any relationship between mu-ERD and MEPs within the action observation condition. Our
findings support the notion that EEG and TMS indices of motor resonance reflect distinct neural mechanisms.

SOURCE: Frontiers in Aging Neuroscience. 14 (no pagination), 2022. Article Number: 993250.

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:394-397, 2022 Jul.

SOURCE: Brain Structure & Function. 227(7):2395-2408, 2022 Sep.

AUTHORS: Behrangrad S; Zoghi M; Kidgell D; Mansouri F; Jaberzadeh S

SOURCE: Frontiers in Human Neuroscience. 16 (no pagination), 2022. Article Number: 969036.