Solute | TMS Resource Portal

Welcome to TMS Solutions' resource portal, Solute, where you will find the latest informative articles about mental health, neuromodulation techniques, and TMS.

Relevant Posts

Sep 30, 2022 5:42:00 PM

Reduced Signal Propagation Elicited by Frontal Transcranial Magnetic Stimulation is Associated With Oligodendrocyte Abnormalities in Treatment-Resistant Depression

SOURCE: Journal of Psychiatry & Neuroscience. 47(5):E325-E335, 2022 Sep-Oct.

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Sep 30, 2022 2:54:00 PM

Neuromodulation of OCD: A Review of Invasive and Non-Invasive Methods

SOURCE: Frontiers in Neurology. 13 (no pagination), 2022. Article Number: 909264.

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Sep 29, 2022 3:42:00 PM

Case Report: Improved Behavioral & Psychiatric Symptoms With rTMS at the Bilateral DLPFC Combined With Cognitive & Behavioral Therapy in a Patient With Unilateral Thalamic Hemorrhage

SOURCE: Frontiers in Neurology. 13 (no pagination), 2022. Article Number: 880161.

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Sep 29, 2022 11:30:00 AM

Targeting CNS Neural Mechanisms of Gait in Stroke Neurorehabilitation

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 1055.

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Sep 28, 2022 5:35:00 PM

Modulation of Spontaneous Motor Unit Potentials by a New Motor Cortical Magnetic Stimulation Method in Amyotrophic Lateral Sclerosis

SOURCE: Journal of Neurology. 269(10):5487-5496, 2022 Oct.

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Sep 28, 2022 2:51:00 PM

Connectomic Disturbances Underlying Insomnia Disorder and Predictors of Treatment Response

SOURCE: Frontiers in Human Neuroscience. 16 (no pagination), 2022. Article Number: 960350.

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Sep 28, 2022 12:11:00 PM

Continuous Theta Burst Stimulation for Drug-Resistant Epilepsy

SOURCE: Frontiers in Neuroscience. 16 (no pagination), 2022. Article Number: 885905.

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Sep 27, 2022 5:28:00 PM

Transcranial Magnetic Stimulation Treatment in Alzheimer's Disease: A Meta-Analysis of its Efficacy as a Function of Protocol Characteristics and Degree of Personalization

SOURCE: Journal of Neurology. 269(10):5283-5301, 2022 Oct.

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Sep 27, 2022 3:35:00 PM

Effects of Repetitive Transcranial Magnetic Stimulation on Upper-Limb and Finger Function in Stroke Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

SOURCE: Frontiers in Neurology. 13 (no pagination), 2022. Article Number: 940467.

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Sep 27, 2022 11:45:00 AM

Effectiveness of Somatosensory Stimulation for the Lower Limb and Foot to Improve Balance and Gait After Stroke: A Systematic Review

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 1102.

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Sep 26, 2022 1:39:00 PM

Different Modalities of Transcranial Magnetic Stimulation to Manage Schizophrenia

SOURCE: The Primary Care Companion to CNS Disorders. 24(4), 2022 Aug 25.

AUTHORS: Soltani E; Bateni H; Shad MU

OBJECTIVE: To analyze all current literature related to different transcranial magnetic stimulation (TMS) modalities in the management of schizophrenia symptoms and compare the main controversies in the outcome measures.

DATA SOURCES: A comprehensive search in Ovid MEDLINE, APA PsycINFO, and PubMed was conducted (1996 to present) to identify all articles using the search terms schizophrenia and single pulse TMS, schizophrenia and paired pulse TMS, schizophrenia and repetitive TMS, schizophrenia and deep TMS, and schizophrenia and TBS.

DATA SELECTION: Search results were limited to the English language and human subjects. Unrelated articles were excluded after the initial review. Nineteen studies fulfilled the eligibility criteria. These studies included 531 schizophrenia patients and 283 healthy controls.

RESULTS: While some adverse effects of TMS are reported, the process is generally considered safe. However, discrepancies exist regarding the length of the cortical silent period. The cortical silent period is thought to be mediated by gamma-aminobutyric acid (GABA) receptors and is
considered a useful probe to assess motor cortical inhibition. It is generally believed that patients with schizophrenia present changes in the cortical silent period due to GABA abnormalities. A few physiologic studies utilized TMS to study motor cortical excitability in schizophrenia and reported longer, and some shorter, cortical silent periods compared with healthy controls. Also, some studies reported a shorter cortical silent period for unmedicated versus medicated patients, while others
reported no differences.

CONCLUSION: TMS treatment is commonly reported to improve auditory hallucination in schizophrenia. Advantage of use of deep TMS over repetitive TMS, however, is controversial.

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Sep 26, 2022 12:01:00 PM

Present Status and Advances in Bladder Pain Syndrome: Central Sensitisation and the Urinary Microbiome

SOURCE: Obstetrician and Gynaecologist. 24(3) (pp 159-166), 2022.

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Sep 25, 2022 6:16:00 PM

Baseline Predictors of Cognitive Change in the Treatment of Major Depressive Episode: Systematic Review

SOURCE: BJPsych Open. 6(6) (no pagination), 2020. Article Number: e131.

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Sep 25, 2022 5:58:00 PM

Cerebellar Repetitive Transcranial Magnetic Stimulation Modulates the Motor Learning of Visually Guided Voluntary Postural Control Task

SOURCE: Neuroscience Letters. 788:136859, 2022 09 25.

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Sep 25, 2022 4:32:00 PM

Design of Optimal Coils for Deep Transcranial Magnetic Stimulation

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:3447-3450, 2022 Jul.

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Sep 25, 2022 10:49:00 AM

Hemodynamic Signal Changes and Swallowing Improvement of Repetitive Transcranial Magnetic Stimulation on Stroke Patients With Dysphagia: A Randomized Controlled Study

SOURCE: Frontiers in Neurology. 13 (no pagination), 2022. Article Number: 918974.

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Sep 24, 2022 6:08:00 PM

Noninvasive Brain Stimulation Therapies to Promote Recovery of Consciousness: Where We Are and Where We Should Go [Review]

SOURCE: Seminars in Neurology. 42(3):348-362, 2022 Jun.

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Sep 24, 2022 4:28:00 PM

Does Resting Motor Threshold Correlate With Severity of Alzheimer's Disease?

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:4383-4386, 2022 Jul.

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Sep 24, 2022 11:41:00 AM

Potential Targets for Noninvasive Brain Stimulation on Depersonalization-Derealization Disorder

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 1112.

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Sep 23, 2022 5:22:00 PM

The Effect of Acute Intermittent Hypoxia on Human Limb Motoneurone Output

SOURCE: Experimental Physiology. 107(6):615-630, 2022 06.

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Sep 23, 2022 1:34:00 PM

Gradual Enhancement of Corticomotor Excitability During Cortico-Cortical Paired Associative Stimulation

SOURCE: Scientific Reports. 12(1):14670, 2022 Aug 29.

AUTHORS: Turrini S; Fiori F; Chiappini E; Santarnecchi E; Romei V; Avenanti A

ABSTRACT: Cortico-cortical paired associative stimulation (ccPAS) is an effective transcranial magnetic stimulation (TMS) method for inducing associative plasticity between interconnected brain areas in humans. Prior ccPAS studies have focused on protocol's aftereffects. Here, we investigated physiological changes induced "online" during ccPAS administration. We tested 109 participants receiving ccPAS over left ventral premotor cortex (PMv) and primary motor cortex (M1) using a standard procedure (90 paired-pulses with 8-ms interstimulus interval, repeated at 0.1 Hz
frequency). On each paired-pulse, we recorded a motor-evoked potential (MEP) to continuously trace the emergence of corticomotor changes. Participant receiving forward-ccPAS (on each pair, a first TMS pulse was administered over PMv, second over M1, i.e., PMv-to-M1) showed a gradual and linear increase in MEP size that did not reach a plateau at the end of the protocol and was greater in participants with low motor threshold. Participants receiving reverse-ccPAS (i.e., M1-to-PMv) showed a trend toward inhibition. Our study highlights the facilitatory and inhibitory modulations that occur during ccPAS administration and suggest that online MEP monitoring could provide insights into the malleability of the motor system and protocol's effectiveness. Our findings open interesting prospects about ccPAS potential optimization in experimental and clinical settings.

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Sep 22, 2022 10:30:00 AM

Human Machine Interface-Based Neuromodulation Solutions for Neurorehabilitation [Editorial]

SOURCE: Frontiers in Neuroscience. 16 (no pagination), 2022. Article Number: 987455.

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Sep 22, 2022 10:24:00 AM

Effects of fMRI-Guided Neural Navigation Based rTMS Therapy on Pain Status in Fibromyalgia Patients

SOURCE: Indian Journal of Physiology and Pharmacology. Conference: 64th Annual National Conference of Association of Physiologists and Pharmacologists of India, APPICON 2018. Karnataka India. 62(Supplement 1) (pp 79), 2018.

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Sep 21, 2022 5:15:00 PM

New Insights into the Effects of Acute Intermittent Hypoxia on Neural Plasticity in the Human Motor System

SOURCE: Experimental Physiology. 107(6):560-561, 2022 06.

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Sep 21, 2022 1:29:00 PM

Imagined Paralysis Reduces Motor Cortex Excitability

SOURCE: Psychophysiology. 59(10):e14069, 2022 Oct.

AUTHORS: Hartmann M; Falconer CJ; Kaelin-Lang A; Muri RM; Mast FW

ABSTRACT: Mental imagery is a powerful capability that engages similar neurophysiological processes that underlie real sensory and motor experiences. Previous studies show that motor cortical excitability can increase during mental imagery of actions. In this study, we focused on possible inhibitory effects of mental imagery on motor functions. We assessed whether imagined arm paralysis modulates motor cortical excitability in healthy participants, as measured by motor evoked potentials (MEPs) of the hand induced by near-threshold transcranial magnetic stimulation (TMS) over the primary motor cortex hand area. We found lower MEP amplitudes during imagined arm paralysis when compared to imagined leg paralysis or baseline stimulation without paralysis imagery. These results show that purely imagined bodily constraints can selectively inhibit basic motor corticospinal functions. The results are discussed in the context of motoric embodiment/disembodiment.

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Sep 21, 2022 10:40:00 AM

Immediate & Short-Term Effects of Continuous Theta Burst TMS Over Contralesional Premotor Area on Post-Stroke Spasticity in Patients With Severe Hemiplegia

TITLE: Immediate and short-term effects of continuous theta burst transcranial magnetic stimulation over contralesional premotor area on post-stroke spasticity in patients with severe hemiplegia: Study protocol for a randomized controlled trial.

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Sep 20, 2022 5:11:00 PM

Depression Induced by Low-Frequency Repetitive Transcranial Magnetic Stimulation to Ventral Medial Frontal Cortex in Monkeys

SOURCE: Experimental Neurology. 357:114168, 2022 Nov.

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Sep 20, 2022 3:13:00 PM

TMS Seeded Diffusion Tensor Imaging Tractography Predicts Permanent Neurological Deficits

SOURCE: Cancers. 14(2) (no pagination), 2022. Article Number: 340.

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Sep 19, 2022 5:07:00 PM

Interhemispheric Inhibition is Different During Arm Cycling Than a Position- and Intensity-Matched Tonic Contraction

SOURCE: Experimental Brain Research. 240(9):2425-2434, 2022 Sep.

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Sep 19, 2022 1:27:00 PM

Exploring the Role of the Left DLPFC in Fatigue During Unresisted Rhythmic Movements

SOURCE: Psychophysiology. 59(10):e14078, 2022 Oct.

AUTHORS: Vila-Villar A; Naya-Fernandez M; Madrid A; Madinabeitia-Mancebo E; Robles-Garcia V; Cudeiro J; Arias P

ABSTRACT: Understanding central fatigue during motor activities is important in neuroscience and different medical fields. The central mechanisms of motor fatigue are known in depth for isometric muscle contractions; however, current knowledge about rhythmic movements and central fatigue is rather scarce. In this study, we explored the role of an executive area (left dorsolateral prefrontal cortex [DLPFC]) in fatigue development during rhythmic movement execution, finger tapping (FT) at the maximal rate, and fatigue after effects on the stability of rhythmic patterns. Participants (n = 19) performed six sets of unresisted FT (with a 3 min rest in-between). Each set included four interleaved 30 s repetitions of self-selected (two repetitions) and maximal rate FT (two repetitions)
without rest in-between. Left DLPFC involvement in the task was perturbed by transcranial static magnetic stimulation (tSMS) in two sessions (one real and one sham). Moreover, half of the self-selected FT repetitions were performed concurrently with a demanding cognitive task, the Stroop
test. Compared with sham stimulation, real tSMS stimulation prevented waning in tapping frequency at the maximal rate without affecting perceived levels of fatigue. Participants ' engagement in the Stroop test just prior to maximal FT reduced the movement amplitude during this mode of execution. Movement variability at self-selected rates increased during Stroop execution, especially under fatigue previously induced by maximal FT. Our results indicate cognitive-motor interactions and a prominent role of the prefrontal cortex in fatigue and the motor control of simple repetitive movement patterns. We suggest the need to approach motor fatigue including cognitive perspectives.

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Sep 19, 2022 11:18:00 AM

Adding a Second iTBS Block in 15 or 60 Min Time Interval Does Not Increase iTBS Effects on Motor Cortex Excitability and the Responder Rates

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 1064.

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Sep 18, 2022 5:52:00 PM

Transcranial Magnetic Stimulation During Gait: A Review of Methodological and Technological Challenges [Review]

SOURCE: Neurology India. 70(4):1448-1453, 2022 Jul-Aug.

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Sep 18, 2022 4:25:00 PM

Discrepant Expressive Language Lateralization in Children and Adolescents With Epilepsy

SOURCE: Annals of Clinical & Translational Neurology. 9(9):1459-1464, 2022 Sep.

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Sep 17, 2022 6:05:00 PM

Comparative Study of Low-Dose Ketamine Infusion and rTMS in Treatment-Resistant Depression: A Posthoc Pooled Analysis of Two Randomized, Double-Blind, Placebo-Controlled Studies

SOURCE: Psychiatry Research. 316:114749, 2022 Oct.

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Sep 17, 2022 4:05:00 PM

Symptom Provocation for Treatment of Obsessive-Compulsive Disorder Using Transcranial Magnetic Stimulation: A Step-by-Step Guide for Professional Training

SOURCE: Frontiers in Psychiatry. 13 (no pagination), 2022. Article Number: 924370.

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Sep 16, 2022 5:04:00 PM

Older Adults' Episodic Memory is Related to a Neurophysiological Marker of Brain Cholinergic Activity

SOURCE: Experimental Brain Research. 240(9):2269-2276, 2022 Sep.

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Sep 16, 2022 1:17:00 PM

The Role of the Primary Motor Cortex in Motor Imagery: A Theta Burst Stimulation Study

SOURCE: Psychophysiology. 59(10):e14077, 2022 Oct.

AUTHORS: Barhoun P; Fuelscher I; Do M; He JL; Cerins A; Bekkali S; Youssef GJ; Corp D; Major BP; Meaney D; Enticott PG; Hyde C

ABSTRACT: While mentally simulated actions activate similar neural structures to overt movement, the role of the primary motor cortex (PMC) in motor imagery remains disputed. The aim of the study was to use continuous theta burst stimulation (cTBS) to modulate corticospinal activity to investigate the putative role of the PMC in implicit motor imagery in young adults with typical and atypical motor ability. A randomized, double blind, sham-controlled, crossover, offline cTBS protocol was applied to 35 young adults. During three separate sessions, adults with typical and low motor
ability (developmental coordination disorder [DCD]), received active cTBS to the PMC and supplementary motor area (SMA), and sham stimulation to either the PMC or SMA. Following stimulation, participants completed measures of motor imagery (i.e., hand rotation task) and visual imagery (i.e., letter number rotation task). Although active cTBS significantly reduced corticospinal excitability in adults with typical motor ability, neither task performance was altered following active cTBS to the PMC or SMA, compared to performance after sham cTBS. These results did not differ
across motor status (i.e., typical motor ability and DCD). These findings are not consistent with our hypothesis that the PMC (and SMA) is directly involved in motor imagery. Instead, previous motor cortical activation observed during motor imagery may be an epiphenomenon of other neurophysiological processes and/or activity within brain regions involved in motor imagery. This study highlights the need to consider multi-session theta burst stimulation application and its neural effects when probing the putative role of motor cortices in motor imagery.

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Sep 15, 2022 6:13:00 PM

Neurophysiological Correlates in Patients with Syringomyelia and Chiari Malformation: The Cortico-Diaphragmatic Involvement

SOURCE: Journal of Clinical Medicine. 11(17) (no pagination), 2022. Article Number: 5080.

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Sep 15, 2022 5:01:00 PM

Neural Effects of Continuous Theta-Burst Stimulation in Macaque Parietal Neurons

SOURCE: eLife. 11, 2022 09 13.

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Sep 15, 2022 3:09:00 PM

Neurostimulation in People with Oropharyngeal Dysphagia: A Systematic Review and Meta-Analysis of Randomised Controlled Trials-Part II: Brain Neurostimulation

SOURCE: Journal of Clinical Medicine. 11(4) (no pagination), 2022. Article Number: 993.

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Sep 14, 2022 1:14:00 PM

Detailed Measurements and Simulations of Electric Field Distribution of Two TMS Coils Cleared for Obsessive Compulsive Disorder in the Brain and in Specific Regions Associated with OCD

SOURCE: PLoS ONE [Electronic Resource]. 17(8):e0263145, 2022.

AUTHORS: Tzirini M; Roth Y; Harmelech T; Zibman S; Pell GS; Kimiskidis VK; Tendler A; Zangen A; Samaras T

ABSTRACT: The FDA cleared deep transcranial magnetic stimulation (Deep TMS) with the H7 coil for obsessive-compulsive disorder (OCD) treatment, following a double-blinded placebo-controlled multicenter trial. Two years later the FDA cleared TMS with the D-B80 coil on the basis of substantial equivalence. In order to investigate the induced electric field characteristics of the two coils, these were placed at the treatment position for OCD over the prefrontal cortex of a head phantom, and the field distribution was measured. Additionally, numerical simulations were performed in eight Population Head Model repository models with two sets of conductivity values and three Virtual Population anatomical head models and their homogeneous versions. The H7 was found to induce significantly higher maximal electric fields (p<0.0001, t = 11.08) and to stimulate two
to five times larger volumes in the brain (p<0.0001, t = 6.71). The rate of decay of electric field with distance is significantly slower for the H7 coil (p < 0.0001, Wilcoxon matched-pairs test). The field at the scalp is 306% of the field at a 3 cm depth with the D-B80, and 155% with the H7 coil. The H7 induces significantly higher intensities in broader volumes within the brain and in specific brain regions known to be implicated in OCD (dorsal anterior cingulate cortex (dACC), dorsolateral prefrontal cortex (dlPFC), inferior frontal gyrus (IFG), orbitofrontal cortex (OFC) and pre-supplementary motor area (pre-SMA)) compared to the D-B80. Significant field >= 80 V/m is induced by the H7 (D-B80) in 15% (1%) of the dACC, 78% (29%) of the pre-SMA, 50% (20%) of the dlPFC, 30% (12%) of the OFC and 15% (1%) of the IFG. Considering the substantial differences between the two coils, the clinical efficacy in OCD should be tested and verified separately for each coil.

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Sep 13, 2022 4:59:00 PM

A Causal Role for the Human Subthalamic Nucleus in Non-Selective Cortico-Motor Inhibition

SOURCE: Current Biology. 32(17):3785-3791.e3, 2022 Sep 12.

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Sep 13, 2022 3:03:00 PM

High-Frequency Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex May Reduce Impulsivity in Patients With Methamphetamine Use Disorders: A Pilot Study

SOURCE: Frontiers in Human Neuroscience. 16 (no pagination), 2022. Article Number: 858465.

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Sep 13, 2022 10:53:00 AM

The Efficacy of Integrated Rehabilitation for Post-Stroke Anxiety: Study Protocol for a Prospective, Multicenter, Randomized Controlled Trial

SOURCE: International Journal of General Medicine. 15 (pp 7101-7111), 2022.

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Sep 12, 2022 4:55:00 PM

Stability and Test-Retest Reliability of Neuronavigated TMS Measures of Corticospinal and Intracortical Excitability

SOURCE: Brain Research. 1794:148057, 2022 Nov 01.

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Sep 12, 2022 1:10:00 PM

Comparative Efficacy of Non-Invasive Brain Stimulation for Post-Stroke Aphasia: A Network Meta-Analysis and Meta-Regression of Moderators [Review]

SOURCE: Neuroscience & Biobehavioral Reviews. 140:104804, 2022 Sep.

AUTHORS: Ding X; Zhang S; Huang W; Zhang S; Zhang L; Hu J; Li J; Ge Q; Wang Y; Ye X; Zhang J

ABSTRACT: In recent years, non-invasive brain stimulation (NIBS) interventions for post-stroke aphasia have received increasing attention, but their effects across different language domains and the influence of targeted locations and moderators remain unclear. Randomized controlled trials (RCTs) on NIBS in patients with post-stroke aphasia were searched. Standardized mean differences (SMDs) for pre-post language changes were pooled in Bayesian network meta-analyses. Moderators were examined using meta-regression. Of the 2105 records identified, 69 RCTs involving 1670 patients were included. Low-frequency (LF)-transcranial magnetic stimulation (rTMS) (SMD
0.84 [0.65,1.03]) was superior to anodal-transcranial direct-current stimulation (a-tDCS) (SMD 0.38 [0.05,0.71]) for global severity. Dual-tDCS was the leading option for naming and repetition. For spontaneous speech, both a-tDCS and dual-tDCS resulted in greater effects than LF-rTMS. As stimulation targets, the right inferior frontal gyrus ranked higher in global severity and spontaneous speech, while the temporoparietal region ranked higher in comprehension. Meta-regression demonstrated that therapeutic effects in the naming domain were moderated by the mean period
of each therapy condition and the first language, while significant associations with age, therapy period, and number of sessions were observed for spontaneous speech. Overall, LF-rTMS is the most prioritized NIBS mode to alleviate global severity. Dual and anodal tDCS outperform rTMS for naming and repetition. The optimal stimulation region varies across different domains.

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Sep 11, 2022 5:48:00 PM

Noninvasive Neuromodulation for Unilateral Neglect After Stroke: A Systematic Review and Network Meta-Analysis [Review]

SOURCE: Neurological Sciences. 43(10):5861-5874, 2022 Oct.

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Sep 11, 2022 4:23:00 PM

'One Region to Control Them All'- The Surprising Effectiveness of Network Control Theory in Predicting Post-Stroke Recovery from Aphasia

SOURCE: Frontiers in Computational Neuroscience. 16 (no pagination), 2022. Article Number: 943396.

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Sep 11, 2022 11:33:00 AM

Continuous Repetition Motor Imagery Training and Physical Practice Training Exert the Growth of Fatigue and Its Effect on Performance

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 1087.

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Sep 10, 2022 3:56:00 PM

Repetitive Transcranial Magnetic Stimulation in Delirium: A Double-blind, Randomized, Sham-Controlled, Pilot Study

SOURCE: Basic and Clinical Neuroscience. 13(2) (pp 237-246), 2022.

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Sep 9, 2022 1:07:00 PM

The Cerebellum is Involved in Motor Improvements After Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease Patients

SOURCE: Neuroscience. 499:1-11, 2022 Sep 01.

AUTHORS: Wen X; Chi S; Yu Y; Wang G; Zhang X; Wang Z; Gesang M; Luo B

ABSTRACT: Accumulating evidence indicates that repetitive transcranial magnetic stimulation (rTMS) ameliorates motor symptoms in patients with Parkinson's disease (PD); however, patients' responses to rTMS are different. Here, we aimed to explore neural activity changes in patients with PD exhibiting different responses to high-frequency rTMS treatments using functional magnetic resonance imaging (fMRI). We treated 24 patients with PD using 10-session rTMS (10 Hz) over the supplementary motor area (SMA) for 10 days. Resting-state functional magnetic resonance imaging (rs-fMRI), the Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) and other neuropsychological scales were performed at the baseline and endpoint of rTMS treatment. The changes in the fractional amplitude of low-frequency fluctuation (fALFF) were calculated. Significant improvements were observed in motor symptoms, especially in the sub-symptoms of
bradykinesia. All the participants were subsequently stratified into responders and non-responders according to the UPDRS-III reduction. We identified increased fALFF values in the left Crus II of the cerebellar hemisphere and bilateral thalamus as responsive signs to rTMS. Furthermore, the motor response to rTMS over the SMA, measured by the reduction in UPDRS-III and bradykinesia scores, was positively associated with increased fALFF values in the left Crus2 of cerebellar hemisphere,
left lobule VIIB of cerebellar hemisphere, right lobule VI of the cerebellar hemisphere, and the right postcentral gyrus. These findings provide evidence for the involvement of cerebellar activity in the motor response to rTMS treatment.

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Sep 8, 2022 4:52:00 PM

Biomagnetic Signals Recorded During Transcranial Magnetic Stimulation (TMS)-Evoked Peripheral Muscular Activity

SOURCE: Biomedizinische Technik. 67(5):333-344, 2022 Oct 26.

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Sep 8, 2022 2:58:00 PM

Use of Repetitive Transcranial Magnetic Stimulation in Child Psychiatry

SOURCE: Innovations in Clinical Neuroscience. 19(4-6) (pp 11-22), 2022.

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Sep 8, 2022 11:26:00 AM

Bilateral Repetitive Transcranial Magnetic Stimulation Ameliorated Sleep Disorder and Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Subjects With Major Depression

SOURCE: Frontiers in Psychiatry. 13 (no pagination), 2022. Article Number: 951595.

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Sep 7, 2022 4:47:00 PM

The Moroccan Arabic Verb and Noun Test for Language Mapping (MAVNT-LP) Under nTMS and DES

SOURCE: Applied Neuropsychology. Adult. 29(6):1413-1424, 2022 Nov-Dec.

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Sep 6, 2022 4:44:00 PM

Investigating the Effects of Anatomical Structures on the Induced Electric Field in the Brain in Transcranial Magnetic Stimulation

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:3939-3942, 2022 Jul.

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Sep 6, 2022 12:30:00 PM

Theta Burst Stimulation in Adults With Symmetric and Asymmetric Visual Acuity

SOURCE: International Ophthalmology. 42(9):2785-2799, 2022 Sep.

AUTHORS: Tuna AR; Pinto N; Fernandes A; Brardo FM; Pato MV

PURPOSE: Theta Burst Stimulation can influence adult neuro-visual response in imbalanced visual pathways, possibly by influencing cortical excitability. Our objective was to compare suppressive imbalance (SI) and visual acuity (VA) after applying repetitive Transcranial Magnetic Stimulation between groups of subjects with normal binocular vision, visual asymmetry, and amblyopia.

METHODS: Thirty-five volunteers between 19 and 51 years of age were split into three groups: 6 volunteers with asymmetric VA (group A); 19 amblyopes (group B); and 10 subjects with normal binocular vision (group C). VA and SI of all groups were evaluated before and after a single session of continuous Theta Burst Stimulation (cTBS) or placebo stimulation over the right occipital cortex.

RESULTS: In both groups A and B, we found a significant VA improvement in the non-dominant eye after cTBS (p = 0.04 and p = 0.01, respectively). In SI evaluation, group A and group B also revealed a significant improvement after the cTBS session (p = 0.03 and p = 0.01, respectively). Finally, in the group of volunteers with normal binocular vision and for placebo groups A and B, there were no significant differences in VA and SI after cTBS.

CONCLUSIONS: Amblyopic and visually asymmetric individuals improved VA and SI of the non-dominant eye after cTBS when compared to baseline and to placebo stimulation. These enhancements were not found in the group of volunteers with normal binocular vision. We can therefore reasonably assume that cTBS may interfere with the visual system of subjects that present some kind of asymmetry, possibly by improving neuronal imbalances.

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Sep 6, 2022 10:44:00 AM

Motor Cortical Plasticity and its Correlation With Motor Symptoms in Parkinson's Disease

SOURCE: eNeurologicalSci. 29 (no pagination), 2022. Article Number: 100422.

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Sep 5, 2022 4:41:00 PM

Characterizing TMS-EEG Perturbation Indexes Using Signal Energy: Initial Study on Alzheimer's Disease Classification

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:398-401, 2022 Jul.

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Sep 5, 2022 12:24:00 PM

A Polygenic-Informed Approach to a Predictive EEG Signature Empowers Antidepressant Treatment Prediction: A Proof-of-Concept Study

SOURCE: European Neuropsychopharmacology. 62:49-60, 2022 Sep.

AUTHORS: Meijs H; Prentice A; Lin BD; De Wilde B; Van Hecke J; Niemegeers P; van Eijk K; Luykx JJ; Arns M

ABSTRACT: The treatment of major depressive disorder (MDD) is hampered by low chances of treatment response in each treatment step, which is partly due to a lack of firmly established outcome-predictive biomarkers. Here, we hypothesize that polygenic-informed EEG signatures may help predict antidepressant treatment response. Using a polygenic-informed electroencephalography (EEG) data-driven, data-reduction approach, we identify a brain network in a large cohort (N=1,123), and discover it is sex-specifically (male patients, N=617) associated with polygenic risk score (PRS) of antidepressant response. Subsequently, we demonstrate in three independent datasets the utility of the network in predicting response to antidepressant medication (male, N=232) as well as repetitive transcranial magnetic stimulation (rTMS) and concurrent psychotherapy (male, N=95). This network significantly improves a treatment response prediction model with age and baseline severity data (area under the curve, AUC=0.623 for medicaton; AUC=0.719 for rTMS). A predictive model for MDD patients, aimed at increasing the likelihood of being a responder to antidepressants or rTMS and concurrent psychotherapy based on only this
network, yields a positive predictive value (PPV) of 69% for medication and 77% for rTMS. Finally, blinded out-of-sample validation of the network as predictor for psychotherapy response in another independent dataset (male, N=50) results in a within-subsample response rate of 50% (improvement of 56%). Overall, the findings provide a first proof-of-concept of a combined genetic and neurophysiological approach in the search for clinically-relevant biomarkers in psychiatric disorders, and should encourage researchers to incorporate genetic information, such as PRS, in their search for clinically relevant neuroimaging biomarkers.

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Sep 4, 2022 5:45:00 PM

Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition

SOURCE: Journal of Visualized Experiments. (186), 2022 Aug 23.

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Sep 4, 2022 4:15:00 PM

Cold Cognition as Predictor of Treatment Response to rTMS: A Retrospective Study on Patients With Unipolar and Bipolar Depression

SOURCE: Frontiers in Human Neuroscience. 16 (no pagination), 2022. Article Number: 888472.

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Sep 3, 2022 6:01:00 PM

A Pilot Study of Accelerated Deep Transcranial Magnetic Stimulation Effects on Cognitive Functioning in Patients Diagnosed With Treatment Resistant Major Depressive Disorder

SOURCE: Psychiatry Research. 316:114750, 2022 Oct.

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Sep 3, 2022 3:47:00 PM

A Novel Perspective of Associativity of Upper Limb Motor Impairment and Cortical Excitability in Sub-Acute and Chronic Stroke

SOURCE: Frontiers in Neuroscience. 16 (no pagination), 2022. Article Number: 832121.

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Sep 3, 2022 11:36:00 AM

Rehabilitation Interventions Combined with Noninvasive Brain Stimulation on Upper Limb Motor Function in Stroke Patients

SOURCE: Brain Sciences. 12(8) (no pagination), 2022. Article Number: 994.

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Sep 2, 2022 4:39:00 PM

High-Frequency rTMS Combined With Task-Specific Hand Motor Training Modulates Corticospinal Plasticity in Motor Complete Spinal Cord Injury: A Case Report

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:2385-2389, 2022 Jul.

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Sep 2, 2022 12:15:00 PM

Mu Rhythm and Corticospinal Excitability Capture Two Different Frames of Motor Resonance: A TMS-EEG Co-Registration Study

SOURCE: Cortex. 154:197-211, 2022 Sep.

Spaccasassi C; Zanon M; Borgomaneri S; Avenanti A

ABSTRACT: Humans are equipped with an extraordinary ability to understand and imitate actions by mapping the observed movement onto their own cortical motor system. Long-established lines of research have identified two correlates of this motor resonance following action observation: the mu rhythm event-related desynchronization (mu-ERD) recorded through electroencephalography (EEG) and the facilitation of motor evoked potentials (MEPs) induced by transcranial magnetic stimulation (TMS) of the primary motor cortex (M1). Yet, whether mu-ERD and MEP facilitation reflect unique or distinct mechanisms is not conclusive, as prior work did not combine simultaneous TMS-EEG recording with a trial-by-trial analysis of the two markers. To address this issue, here, we used TMS-EEG co-registration while participants observed and executed finger movements. EEG was continuously recorded while single-pulse TMS was administered over the left M1 and MEPs were recorded from the right hand. We found stronger motor cortex recruitment during action execution and observation as shown by mu-ERD. MEPs instead were larger overall during action execution and showed a facilitation specific to the muscles involved in the observed movements. Interestingly, when analyzing these two parameters using a trial-by-trial statistical approach, we did not find any relationship between mu-ERD and MEPs within the action observation condition. Our
findings support the notion that EEG and TMS indices of motor resonance reflect distinct neural mechanisms.

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Sep 2, 2022 10:33:00 AM

The Efficacy of Therapies for Post-Stroke Depression in Aging: An Umbrella Review

SOURCE: Frontiers in Aging Neuroscience. 14 (no pagination), 2022. Article Number: 993250.

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Sep 1, 2022 4:35:00 PM

Preliminary Study on the Impact of EEG Density on TMS-EEG Classification in Alzheimer's Disease

SOURCE: Annual International Conference Of The IEEE Engineering In Medicine And Biology Society. 2022:394-397, 2022 Jul.

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Sep 1, 2022 12:11:00 PM

The Effects of Concurrent Bilateral Anodal tDCS of Primary Motor Cortex and Cerebellum on Corticospinal Excitability: A Randomized, Double-Blind Sham-Controlled Study

SOURCE: Brain Structure & Function. 227(7):2395-2408, 2022 Sep.

AUTHORS: Behrangrad S; Zoghi M; Kidgell D; Mansouri F; Jaberzadeh S

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Sep 1, 2022 12:06:00 PM

The Effects of Robot-Assisted Gait Training Combined With Non-Invasive Brain Stimulation on Lower Limb Function in Patients With Stroke and Spinal Cord Injury: A Systematic Review and Meta-Analysis

SOURCE: Frontiers in Human Neuroscience. 16 (no pagination), 2022. Article Number: 969036.

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