Solute | TMS Resource Portal

Welcome to TMS Solutions' resource portal, Solute, where you will find the latest informative articles about mental health, neuromodulation techniques, and TMS.

Relevant Posts

Feb 28, 2022 5:08:00 PM

Prolonged Continuous Theta Burst Stimulation to Demonstrate a Larger Analgesia as Well as Cortical Excitability Changes Dependent on the Context of a Pain Episode

Source: Frontiers in Aging Neuroscience. 13 (no pagination), 2022. Article Number:
804362.
Date of Publication: 28 Jan 2022.

Authors:
Liu Y.; Yu L.; Che X.; Yan M.

Abstract:
A series of neuropathic pain conditions have a prevalence in older adults
potentially associated with declined functioning of the peripheral and/or central nervous system. Neuropathic pain conditions demonstrate defective cortical excitability and intermissions, which raises questions of the impact of pain on cortical excitability changes and when to deliver repetitive transcranial magnetic stimulation (rTMS) to maximize the analgesic effects. Using prolonged continuous theta-burst stimulation (pcTBS), a relatively new rTMS protocol to increase excitability, this study was designed to investigate pcTBS analgesia and cortical
excitability in the context of pain. With capsaicin application, twenty-nine healthy participants received pcTBS or Sham stimulation either in the phase of pain initialization (capsaicin applied) or pain ascending (20 min after capsaicin application). Pain intensity was measured with a visual-analogic scale (VAS). Cortical excitability was assessed by motor-evoked potential (MEP) and cortical silent period (CSP) which evaluates corticospinal excitability and GABAergic intracortical inhibition, respectively. Our data on pain dynamics demonstrated that
pcTBS produced a consistent analgesic effect regardless of the time frame of pcTBS. More importantly, pcTBS delivered at pain initialization induced a larger pain reduction and a higher response rate compared to the stimulation during pain ascending. We further provide novel findings indicating distinct mechanisms of pcTBS analgesia dependent on the context of pain, in which pcTBS delivered at pain initialization was able to reverse depressed MEP, whereby pcTBS during pain ascending was associated with increased CSP. Overall, our data indicate pcTBS to be a potential protocol in pain management that could be delivered before the
initialization of a pain episode to improve rTMS analgesia, potentially through inducing early corticospinal excitability changes that would be suppressed by nociceptive transmission.

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Feb 28, 2022 3:29:00 PM

Left Dorsolateral Prefrontal Cortex Glx/tCr Predicts Efficacy of High Frequency 4- to 6-Week rTMS Treatment & Is Associated With Symptom Improvement in Adults With MDD: Findings From a Pilot Study

Source: Frontiers in Psychiatry. 12 (no pagination), 2021. Article Number: 665347.

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Feb 27, 2022 5:13:00 PM

Repetitive Transcranial Magnetic Stimulation for Neuropathic Pain: A Randomized Multicentre Sham-Controlled Trial

Source: Brain. 144(11):3328-3339, 2021 12 16.

Authors:
Attal N; Poindessous-Jazat F; De Chauvigny E; Quesada C; Mhalla A; Ayache SS; Fermanian C; Nizard J; Peyron R; Lefaucheur JP; Bouhassira D

Abstract:
Repetitive transcranial magnetic stimulation (rTMS) has been proposed to
treat neuropathic pain but the quality of evidence remains low. We aimed to assess the efficacy and safety of neuronavigated rTMS to the primary motor cortex (M1) or dorsolateral prefrontal cortex (DLPFC) in neuropathic pain over 25 weeks. We carried out a randomized double-blind, placebo-controlled trial at four outpatient clinics in France. Patients aged 18-75 years with peripheral neuropathic pain were randomly assigned at a 1:1 ratio to M1 or DLPFC-rTMS and rerandomized at a 2:1 ratio to active or sham-rTMS (10 Hz, 3000 pulses/session, 15 sessions over 22 weeks). Patients and investigators were blind to treatment allocation. The primary end point was the comparison between active M1-rTMS, active DLPCF-rTMS and sham-rTMS for the change over the course of 25 weeks (Group x Time interaction) in average pain intensity (from 0 no pain to 10 maximal pain) on the Brief Pain Inventory, using a mixed model repeated measures analysis in patients who received at least one rTMS session (modified intention-to-treat population). Secondary outcomes included other measures of pain intensity and relief, sensory and affective dimensions of pain, quality of pain, self-reported pain intensity and
fatigue (patients diary), Patient and Clinician Global Impression of Change (PGIC, CGIC), quality of life, sleep, mood and catastrophizing. This study is registered with ClinicalTrials.gov NCT02010281. A total of 152 patients were randomized and 149 received treatment (49 for M1; 52 for DLPFC; 48 for sham). M1-rTMS reduced pain intensity versus sham-rTMS (estimate for Group x Session interaction: -0.048 +/- 0.02; 95% CI: -0.09 to -0.01; P = 0.01). DLPFC-rTMS was not better than sham (estimate: -0.003 +/- 0.01; 95% CI: -0.04 to 0.03, P = 0.9). M1-rRMS, but not DLPFC-rTMS, was also superior to sham-rTMS on pain relief, sensory dimension of pain,
self-reported pain intensity and fatigue, PGIC and CGIC. There were no effects on quality of pain, mood, sleep and quality of life as all groups improved similarly over time. Headache was the most common side effect and occurred in 17 (34.7%), 23 (44.2%) and 13 (27.1%) patients from M1, DLPFC and sham groups, respectively (P = 0.2). Our results support the clinical relevance of M1-rTMS, but not of DLPFC-rTMS, for peripheral neuropathic pain with an excellent safety profile.

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Feb 27, 2022 4:06:00 PM

Impact of Operator Experience on Transcranial Magnetic Stimulation

Source: Clinical Neurophysiology Practice. 7 (pp 42-48), 2022.

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Feb 26, 2022 3:50:00 PM

Prefrontal Transcranial Magnetic Stimulation for Depression in US Military Veterans - A Naturalistic Cohort Study in the Veterans Health Administration

Source: Journal of Affective Disorders. 297:671-678, 2022 01 15.

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Feb 24, 2022 5:33:00 PM

Beyond the Cuckoo's Nest: Patient and Public Attitudes about Psychiatric Electroceutical Interventions

Source: Psychiatric Quarterly. 92(4):1425-1438, 2021 12.

Authors:
Cabrera LY; Gilbert MMC; McCright AM; Achtyes ED; Bluhm R

Abstract:
Recent research emphasizes the role of psychiatric electroceutical
interventions (PEIs), bioelectronic treatments that employ electrical stimulation to affect and modify brain function, to effectively treat psychiatric disorders. We sought to examine attitudes about three PEIs-electroconvulsive therapy, transcranial magnetic stimulation, and deep brain stimulation-among patients with depression and members of the general public. As part of a larger study to assess different stakeholders' attitudes about PEIs, we conducted semi-structured key
informant interviews with 16 individuals living with depression and 16 non-depressive members of the general public. We used a purposive sampling approach to recruit potential participants based on eligibility criteria. We performed qualitative content analysis of interview transcripts. Participants from both groups expressed an overall cautionary attitude towards PEIs, yet there were mixed attitudes in both groups. Patients commonly described electroconvulsive therapy as scary, traumatic, or intense, while members of the general public often referenced the treatment's negative portrayal in One Flew over the Cuckoo's Nest.
Patients and the general public saw transcranial magnetic stimulation as a potentially viable option, but in most cases only if medication was not effective. Deep brain stimulation attitudes were predominantly negative among patients and cautionary among public. The overall cautionary attitudes towards PEIs, together with the technological features and social aspects underlying those attitudes, highlight the need for unbiased education to fill the gaps in knowledge and inform perceptions of those who may benefit from these treatments.

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Feb 24, 2022 4:47:00 PM

Therapeutic Application of rTMS in Neurodegenerative and Movement Disorders: A Review

Source: Journal of Electromyography & Kinesiology. 62:102622, 2022 Feb.

Authors:
Pateraki G; Anargyros K; Aloizou AM; Siokas V; Bakirtzis C; Liampas I; Tsouris Z; Ziogka P; Sgantzos M; Folia V; Peristeri E; Dardiotis E

Abstract:
Transcranial magnetic stimulation (TMS) is a non-invasive form of brain
stimulation that makes use of the magnetic field generated when an electric current passes through a magnetic coil placed over the scalp. It can be applied as a single stimulus at a time, in pairs of stimuli, or repetitively in trains of stimuli (repetitive TMS, rTMS). RTMS can induce changes in brain activity, whose after-effects reflect the processes of long-term potentiation and long-term depression, as certain protocols, namely those using low frequencies (<=1 Hz) seem to suppress cortical excitability, while those using high frequencies (>1 Hz) seem to enhance it. It is a technique with very few and mostly mild side-effects, whose
effects can persist for long time periods, and as such, it has been studied as a potential treatment option in a multitude of neurodegenerative diseases, including those affecting movement. Although rTMS has received approval as a treatment strategy of only a few aspects in movement disorders in the latest guidelines, its further use seems to also be promising in their context. In this review, we gathered the available literature on the therapeutic application of rTMS in movement disorders, namely Parkinson's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Dystonia, Tic disorders and Essential Tremor.

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Feb 24, 2022 3:20:00 PM

Cortical Inhibition and Plasticity in Major Depressive Disorder

Source: Frontiers in Psychiatry. 13 (no pagination), 2022. Article Number: 777422.

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Feb 23, 2022 5:49:00 PM

Local and Transient Changes of Sleep Spindle Density During Series of Prefrontal Repetitive Transcranial Magnetic Stimulation in Patients With a Major Depressive Episode

Source: Frontiers in Human Neuroscience. 15 (no pagination), 2021. Article Number:
738605.

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Feb 22, 2022 4:43:00 PM

A Combination of P300 and Eye Movement Data Improves the Accuracy of Auxiliary Diagnoses of Depression

Source: Journal of Affective Disorders. 297:386-395, 2022 01 15.

Authors:
Diao Y; Geng M; Fu Y; Wang H; Liu C; Gu J; Dong J; Mu J; Liu X; Wang C

Abstract

BACKGROUND: Exploratory eye movements (EEMs) and P300 are often used to facilitate the clinical diagnosis of depression. However, There were few studies using the combination of EEMs and P300 to build a model for detecting depression and predicting a curative effect.

METHODS: Sixty patients were recruited for 2 groups: high frequency repetitive transcranial magnetic stimulation(rTMS) combined with paroxetine group and simple paroxetine group. Clinical efficacy was evaluated by the Hamilton Depression scale-24(HAMD-24), EEMs and P300. The classification model of the auxiliary diagnosis of depression and the prediction model of the two treatments were developed based on a machine learning algorithm.

RESULTS: The classification model with the greatest accuracy for patients with depression and healthy controls was 95.24% (AUC = 0.75, recall = 1.00, precision = 0.95, F1-score = 0.97). The root mean square error (RMSE) of the model for predicting the efficacy of high frequency rTMS combined with paroxetine was 3.54 (MAE [mean absolute error] = 2.56, R2 = -0.53). The RMSE of the model for predicting the efficacy of paroxetine was 4.97 (MAE = 4.00, R2 = -0.91).

CONCLUSION: Based on the machine learning algorithm, P300 and EEMs data
was suitable for modeling to distinguish depression patients and healthy individuals. However, it was not suitable for predicting the efficacy of high frequency rTMS combined with paroxetine or to predict the efficacy of paroxetine.

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Feb 22, 2022 3:14:00 PM

Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Mild Cognitive Impairment: A Meta-Analysis of Randomized Controlled Trials

Source: Frontiers in Human Neuroscience. 15 (no pagination), 2021. Article Number:
723715.

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Feb 22, 2022 11:03:00 AM

Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Chronic Subjective Tinnitus

Source: Brain Sciences. 12(2) (no pagination), 2022. Article Number: 203.

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Feb 21, 2022 3:09:00 PM

White Matter Markers and Predictors for Subject-Specific rTMS Response in Major Depressive Disorder

Source: Journal of Affective Disorders. 299:207-214, 2022 02 15.

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Feb 20, 2022 4:02:00 PM

Bilateral Orbitofrontal Repetitive Transcranial Magnetic Stimulation in Frontal Lobe Epilepsy: A Case Report

Source: Case Reports in Neurology. 13(3) (pp 729-737), 2021.

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Feb 19, 2022 3:44:00 PM

Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive Disorder

Source: Brain Sciences. 12(1) (no pagination), 2022. Article Number: 112.

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Feb 19, 2022 10:51:00 AM

Effect of Theta Burst Stimulation-Patterned rTMS on Motor and Nonmotor Dysfunction of Parkinson's Disease: A Systematic Review and Meta-Analysis

Source: Frontiers in Neurology. 12 (no pagination), 2021. Article Number: 762100.

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Feb 18, 2022 4:31:00 PM

Non-Invasive Brain Stimulation to Treat Disorders of Human Verticality

Source: Neurologie und Rehabilitation. 25 (pp S50-S53), 2019.

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Feb 18, 2022 3:06:00 PM

Increased Motor Cortex Inhibition as a Marker of Compensation to Chronic Pain in Knee Osteoarthritis

Source: Scientific Reports. 11(1):24011, 2021 12 14.

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Feb 17, 2022 5:46:00 PM

Repetitive Transcranial Magnetic Stimulation (rTMS) as Therapy in an Infant With Epilepsia Partialis Continua

Source: Epilepsy and Behavior Reports. 18 (no pagination), 2022. Article Number:
100511.

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Feb 17, 2022 3:02:00 PM

Serum Mature BDNF Level Is Associated with Remission Following ECT in Treatment-Resistant Depression

Source: Brain Sciences. 12(2) (no pagination), 2022. Article Number: 126.

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Feb 16, 2022 4:50:00 PM

Efficacy and Acceptability of Noninvasive Brain Stimulation Interventions for Weight Reduction in Obesity: A Pilot Network Meta-Analysis

Source: International Journal of Obesity. 45(8):1705-1716, 2021 08.

Authors:
Zeng BY; Zeng BS; Chen YW; Hung CM; Sun CK; Cheng YS; Stubbs B; Carvalho AF; Brunoni AR; Su KP; Tu YK; Wu YC; Chen TY; Lin PY; Liang CS; Hsu CW;
Tseng PT; Li CT

Abstract

BACKGROUND/OBJECTIVES: Obesity has recently been recognized as a neurocognitive disorder involving circuits associated with the reward system and the dorsolateral prefrontal cortex (DLPFC). Noninvasive brain stimulation (NIBS) has been proposed as a strategy for the management of obesity. However, the results have been inconclusive. The aim of the current network meta-analysis (NMA) was to evaluate the efficacy and acceptability of different NIBS modalities for weight reduction in participants with obesity.

METHODS: Randomized controlled trials (RCTs) examining NIBS interventions in patients with obesity were analyzed using the frequentist model of NMA. The coprimary outcome was change in body mass index (BMI) and acceptability, which was calculated using the dropout rate.

RESULTS: Overall, the current NMA, consisting of eight RCTs, revealed that the high-frequency repetitive transcranial magnetic stimulation (TMS) over the left DLPFC was ranked to be associated with the second-largest decrease in BMI and the largest decrease in total energy intake and craving severity, whereas the high-frequency deep TMS over bilateral DLPFC and the insula was ranked to be associated with the largest decrease in BMI.

CONCLUSION: This pilot study provided a "signal" for the design of more methodologically robust and larger RCTs based on the findings of the potentially beneficial effect on weight reduction in participants with obesity by different NIBS interventions.

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Feb 15, 2022 4:39:00 PM

Predictive Roles of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Antidepressant Efficacy of Different Forms of Prefrontal Brain Stimulation Monotherapy

Source: Journal of Affective Disorders. 297:353-359, 2022 01 15.

Authors:
Cheng CM; Hong CJ; Lin HC; Chu PJ; Chen MH; Tu PC; Bai YM; Chang WH; JuanCH; Lin WC; Tsai SJ; Su TP; Li CT

Abstract

BACKGROUND: Although repetitive transcranial magnetic stimulation (rTMS) and prolonged intermittent theta-burst stimulation (piTBS) can induce changes in synaptic plasticity, the influence of brain-derived neurotrophic factor (BDNF) genotypes on their antidepressant effects remain unknown. Hence, we investigated the BDNF polymorphism contribution to the antidepressant effect of different forms left-sided prefrontal stimulations in a randomized, sham-controlled study METHODS: Seventy-five patients with medication-resistant depression were randomly assigned into three monotherapy groups: piTBS, high-frequency(HF) rTMS, or sham. The acute treatment period was two weeks. 17-item Hamilton Depression Rating scale (HDRS-17) were applied at baseline, week-1, and week-2. The primary outcome was percentage changes of HDRS-17 (%HDRS-17 changes) analyzed by generalized estimating equation (GEE) model.

RESULTS: The GEE analysis revealed a significant interaction between group, time, and BDNF genotypes effects on %HDRS-17 changes over time. In patients carrying Val homozygotes, piTBS and HF-rTMS both exhibited significantly greater %HDRS reduction than sham at week-2. In Met carriers, only piTBS showed better efficacy than sham at week-2 (piTBS vs. sham, -41.1% vs.-18.9%, p=0.004). Regarding the influence of different BDNF genotypes on antidepressant efficacy in each intervention, only HF-rTMS exhibited significantly different degrees of %HDRS-17 changes between Val homozygotes and Met carriers (-68.5% vs. -26.4%, p=0.012,
respectively), but piTBS delivered the consistent efficacy regardless of the BDNF polymorphism.

CONCLUSIONS: This is the first study to confirm the different impacts of BDNF genotypes on the effect of different left-sided prefrontal brain stimulation. BDNF Val66Met polymorphism may play a role in the antidepressant response of piTBS and HF-rTMS.

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Feb 15, 2022 4:27:00 PM

High-Frequency rTMS Over the Left Dorsolateral Prefrontal Cortex Shortly Alleviates Fatigue in Patients With Multiple System Atrophy: A Randomized Controlled Trial

Source: Frontiers in Neurology. 12 (no pagination), 2022. Article Number: 755352.

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Feb 15, 2022 3:00:00 PM

Brain SPECT as an Imaging Biomarker for Evaluating Effects of Novel Treatments in Psychiatry - A Case Series

Source: Frontiers in Psychiatry. 12 (no pagination), 2021. Article Number: 713141.

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Feb 14, 2022 2:57:00 PM

Predictors of Clinical Response After rTMS Treatment of Patients Suffering From Drug-Resistant Depression

Source: Transl Psychiatry Psychiatry. 11(1):587, 2021 11 15.

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Feb 13, 2022 5:05:00 PM

Transcranial Direct Current Stimulation Improve Symptoms and Modulates Cortical Inhibition in Obsessive-Compulsive Disorder: A TMS-EEG Study

Source: Journal of Affective Disorders. 298(Pt A):558-564, 2022 02 01.

Authors:
Cheng J; Li P; Tang Y; Zhang C; Lin L; Gao J; Wang Z

Abstract

BACKGROUND: Obsessive-compulsive disorder (OCD) is a disabling condition for which approximately 40% of patients do not respond to first-line treatment. Transcranial direct current stimulation (tDCS) is a safe and accessible technique that modulates cortical excitability and inhibition, but evidence of its efficacy for OCD is insufficient.

OBJECTIVE: To investigate the efficacy of tDCS for OCD and alterations of cortical excitability and inhibition after treatment measured by concurrent transcranial magnetic stimulation-electroencephalography (TMS-EEG).

METHODS: Twenty-four OCD patients underwent 10 20-min sessions of 1.5 mA high-definition tDCS with a cathode placed over the right orbitofrontal cortex (OFC) and anode electrodes set around the cathodal electrode. TMS-EEG was performed before and after tDCS treatment. OCD symptom severitys was assessed using Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and the Beck Depression Inventory-II (BDI-II), and Beck Anxiety Inventory (BAI) were used to assess the severity of depression and anxiety symptoms. Twenty-seven healthy controls were recruited with TMS-EEG recorded.

RESULTS: Following tDCS, the Y-BOCS, BDI-II, and BAI scores decreased significantly (all p = 0.000). TMS-evoked N100 amplitude, thought to be related to GABAB receptor function, was significantly reduced after tDCS (Z = -2.143, p = 0.032) which was higher in OCD patients than in healthy controls at baseline (Z = -2.151, p = 0.031).

LIMITATIONS: Pharmacotherapy during tDCS treatment may influence the effect of tDCS and EEG.

CONCLUSIONS: Cathodal high-definition tDCS applied over the OFC could improve OCD, depression, and anxiety symptoms along with alleviation of GABAB receptor function.

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Feb 12, 2022 3:41:00 PM

Transcranial Magnetic Stimulation (TMS) for Geriatric Depression [Review]

Source: Ageing Research Reviews. 74:101531, 2022 02.

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Feb 11, 2022 5:17:00 PM

Brain Connectivity and Symptom Changes After Transcranial Magnetic Stimulation in Patients With Borderline Personality Disorder

Source: Frontiers in Psychiatry. 12 (no pagination), 2021. Article Number: 770353.

Date of Publication:
18 Jan 2022.

Authors:
Sverak T.; Linhartova P.; Gajdos M.; Kuhn M.; Latalova A.; Lamos M.; Ustohal L.; Kasparek T.

Abstract

OBJECTIVES: Repetitive transcranial magnetic stimulation (rTMS) is an innovative method in the treatment of borderline personality disorder (BPD). We hypothesized that prefrontal rTMS in patients with BPD leads to improved BPD symptoms and that these effects are associated with brain connectivity changes.

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Feb 11, 2022 2:53:00 PM

Functional Neuromarkers for Psychiatry and Neurology: Applications for Diagnosis and Treatment

Source: NeuroRegulation. Conference: 29th International Society for
Neuroregulation and Research, ISNR 2021. Miami, FL United States. 8(4) (pp
198-199), 2021.

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Feb 10, 2022 6:02:00 PM

Comparison of the Effect and Treatment Sequence Between a 2-Week Parallel rTMS & Rehabilitation & a 2-Week Rehabilitation-Only Intervention

TITLE: Comparison of the Effect and Treatment Sequence Between a 2-Week Parallel Repetitive Transcranial Magnetic Stimulation and Rehabilitation and a 2-Week Rehabilitation-Only Intervention During a 4-Week Hospitalization for Upper Limb Paralysis After Stroke: An Open-Label, Crossover Observational Study

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Feb 10, 2022 4:22:00 PM

Effects of Non-Invasive Brain Stimulation in Multiple Sclerosis: Systematic Review and Meta-Analysis

Source: Therapeutic Advances in Chronic Disease. 13 (no pagination), 2022.

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Feb 10, 2022 2:50:00 PM

Transdiagnostic Symptom Subtypes to Predict Response to Therapeutic Transcranial Magnetic Stimulation in Major Depressive Disorder and Posttraumatic Stress Disorder

Source: Journal of Personalized Medicine. 12(2) (no pagination), 2022. Article
Number: 224.

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Feb 9, 2022 5:21:00 PM

Systematic Review of Preservation TMS That Includes Continuation, Maintenance, Relapse-Prevention, and Rescue TMS [Review]

Source: Journal of Affective Disorders. 296:79-88, 2022 01 01.

Authors:
Wilson S; Croarkin PE; Aaronson ST; Carpenter LL; Cochran M; Stultz DJ;
Kozel FA

Abstract

BACKGROUND: A dearth of evidence-based information exists to guide the delivery of transcranial magnetic stimulation (TMS) after a successful acute course of treatment for Major Depressive Disorder.

METHODS: To provide guidance for clinicians, existing literature focused on "preservation TMS" was systematically reviewed and synthesized. Preservation TMS was defined as TMS used to sustain a clinical response after a successful acute course of treatment and included reports using the terms maintenance, continuation, relapse prevention, or rescue TMS. The review protocol was registered on Open Science Framework and reported following PRISMA guidelines. Data were abstracted by two authors and discrepancies were resolved by a third author. Primary outcome measures focused on clinical efficacy. The evaluated studies were graded using the Levels of Evidence criteria published by the Oxford Centre for Evidence-Based Medicine.

RESULTS: The search included 536 abstracts and 16 additional papers, from which 63 full articles were screened. Data were abstracted from 30 qualifying sources (N=1,494) including 4 randomized controlled trials (one sham controlled), 14 open trials, and 12 case series. Overall, the quality of existing literature was low regarding efficacy but provided clear support for effectiveness and safety across a range of preservation TMS protocols based on mostly uncontrolled studies.

CONCLUSIONS: Existing literature suggests that preservation TMS protocols significantly vary and are mostly supported by open trials and case series. Due to a lack of effective alternatives, preservation TMS will likely be required for certain patients who respond to acute TMS therapy. More studies of preservation TMS are critically needed.

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Feb 9, 2022 2:45:00 PM

Repetitive Transcranial Magnetic Stimulation Modulates Frontal and Temporal Time-Varying EEG Network in Generalized Anxiety Disorder: A Pilot Study

Source: Frontiers in Psychiatry. 12 (no pagination), 2022. Article Number: 779201.

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Feb 9, 2022 10:56:00 AM

Effects of Cortical Intermittent Theta-burst Stimulation Combined With Precise Root Stimulation on Motor Function After Spinal Cord Injury: A Case Series Study

Source: Neural Regeneration Research. 17(8) (pp 1821-1826), 2022.

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Feb 8, 2022 4:18:00 PM

The Long-Term Effect of Treatment Using the Transcranial Magnetic Stimulation rTMS in Patients After Incomplete Cervical or Thoracic Spinal Cord Injury

Source: Journal of Clinical Medicine. 10(13) (no pagination), 2021. Article
Number: 2975.

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Feb 8, 2022 2:01:00 PM

Efficacy of Deep TMS with the H1 Coil for Anxious Depression

Source: Journal of Clinical Medicine. 11(4) (no pagination), 2022. Article Number:
1015.

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Feb 7, 2022 1:57:00 PM

Application of Repetitive Transcranial Magnetic Stimulation over the Dorsolateral Prefrontal Cortex in Alzheimer's Disease: A Pilot Study

Source: Journal of Clinical Medicine. 11(3) (no pagination), 2022. Article Number:
798.

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Feb 6, 2022 5:37:00 PM

Repetitive Transcranial Magnetic Stimulation as a Therapeutic and Probe in Schizophrenia: Examining the Role of Neuroimaging and Future Directions [Review]

Source: Neurotherapeutics. 18(2):827-844, 2021 04.

Authors:
Brandt SJ; Oral HY; Arellano-Bravo C; Plawecki MH; Hummer TA; Francis MM

Abstract:
Schizophrenia is a complex condition associated with perceptual disturbances, decreased motivation and affect, and disrupted cognition. Individuals living with schizophrenia may experience myriad poor outcomes, including impairment in independent living and function as well as decreased life expectancy. Though existing treatments may offer benefit, many individuals still experience treatment resistant and disabling symptoms. In light of the negative outcomes associated with schizophrenia and the limitations in currently available treatments, there is a significant need for novel therapeutic interventions. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that can modulate the activity of discrete cortical regions, allowing direct manipulation of local brain activation and indirect manipulation of the target's associated neural networks. rTMS has been studied in schizophrenia for the treatment of auditory hallucinations, negative symptoms, and cognitive deficits, with mixed results. The field's inability to arrive at a consensus on the use rTMS in schizophrenia has stemmed from a variety of issues, perhaps most notably
the significant heterogeneity amongst existing trials. In addition, it is likely that factors specific to schizophrenia, rather than the rTMS itself, have presented barriers to the interpretation of existing results. However, advances in approaches to rTMS as a biologic probe and therapeutic, many of which include the integration of neuroimaging with rTMS, offer hope that this technology may still play a role in improving the understanding and treatment of schizophrenia.

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Feb 5, 2022 5:29:00 PM

Neuro-Doping as a Means to Avert Fascistoid Ideology in Elite Sport

Source: Neuroethics. 14(Supplement 2) (pp 169-178), 2021.

Date of Publication: November 2021.

Author:
Tannsjo T.

Abstract:
Assume that neuro-doping is safe and efficient. This means that the use of it, and similar future safe methods of enhancement in sport, may help those who are naturally weak to catch up with those who are naturally strong and sometimes even defeat them. The rationale behind anti-doping measures seem to presuppose that this is unfair. But the idea that those who are naturally strong should defeat those who are naturally weak rests on a fascistoid ideology that sport had better leave behind. Neuro-doping may be seen as a means to undermine the fascistoid notion of fairness. The conjecture is that, given that society adopts what will be characterized as a policy of biological egalitarianism, this will happen. Then people will compete in society in general and in sport in particular on more equal biological terms. The fascination with natural strength, and the cheering for the winners, can then go away. Instead we see a liberated
sport where we take part in it for the sheer fun of doing so. Neuro-doping, and similar techniques, may be a means that helps to liberate elite sport from its perverse view of fairness.

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Feb 5, 2022 3:33:00 PM

Qeeg and Loreta Monitoring of Repetitive Transcranial Magnetic Stimulation for Medication Resistant Depression

Source: NeuroRegulation Conference: 29th International Society for Neuroregulation and Research, ISNR 2021. Miami, FL United States. 8(4) (pp
209-210), 2021.

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Feb 4, 2022 4:13:00 PM

A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression

Source: Frontiers in Psychiatry. 12 (no pagination), 2021. Article Number: 784830.

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Feb 4, 2022 1:54:00 PM

Efficacy of Non-Invasive Brain Stimulation on Global Cognition and Neuropsychiatric Symptoms in Alzheimer's Disease and Mild Cognitive Impairment: A Meta-Analysis and Systematic Review

Source: Ageing Research Reviews. 72:101499, 2021 12.

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Feb 3, 2022 5:53:00 PM

A Clinical Trial to Assess the Role of Repetitive Transcranial Magnetic Stimulation in Smoking Cessation in an Egyptian Sample

Source: Addictive Disorders and their Treatment. 20(4) (pp 554-566), 2021.

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Feb 3, 2022 5:24:00 PM

Review of Noninvasive or Minimally Invasive Deep Brain Stimulation

Source: Frontiers in Behavioral Neuroscience. 15 (no pagination), 2022. Article
Number: 820017.
Date of Publication: 18 Jan 2022.

Authors:
Liu X.; Qiu F.; Hou L.; Wang X.

Abstract:
Brain stimulation is a critical technique in neuroscience research and
clinical application. Traditional transcranial brain stimulation techniques, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS) have been widely investigated in neuroscience for decades. However, TMS and tDCS have poor spatial resolution and penetration depth, and DBS requires electrode implantation in deep brain structures. These disadvantages have limited the clinical applications of these techniques. Owing to developments in science and technology, substantial advances in noninvasive and precise deep stimulation have been achieved by
neuromodulation studies. Second-generation brain stimulation techniques that mainly rely on acoustic, electronic, optical, and magnetic signals, such as focused ultrasound, temporal interference, near-infrared optogenetic, and nanomaterial-enabled magnetic stimulation, offer great prospects for neuromodulation. This review summarized the mechanisms, development, applications, and strengths of these techniques and the  prospects and challenges in their development. We believe that these second-generation brain stimulation techniques pave the way for brain disorder therapy.

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Feb 3, 2022 1:49:00 PM

Regionally Specific Gray Matter Volume is Lower in Alcohol Use Disorder: Implications for Noninvasive Brain Stimulation Treatment

Source: Alcoholism: Clinical & Experimental Research. 45(8):1672-1683, 2021 08.

Authors:
McCalley DM; Hanlon CA

Abstract

BACKGROUND: There is growing interest in neuromodulation-based therapeutics as tools for individuals with alcohol use disorder (AUD). Through electromagnetic induction, techniques such as transcranial magnetic stimulation (TMS) can noninvasively depolarize cortical cells in the induced electrical field and monosynaptic afferents. The ability of TMS to modulate the brain is dependent upon two factors, which may be compromised in individuals with AUD: (1) gray matter volume (GMV) at the site of stimulation and (2) scalp-to-cortex (STC) distance. This study tested the hypotheses that these aspects of neural architecture are compromised in AUD patients, and thus AUD patients may need a higher TMS dose to depolarize the cortex.

METHODS: High-resolution magnetic resonance images were acquired from 44 individuals with AUD and 44 age-matched healthy controls (n = 88). Whole-brain voxel-based morphometry was conducted. Subsequent region-of-interest analysis was performed at three EEG 10-20 sites commonly used in TMS for AUD: FP1 (left frontal pole), F3 (left DLPFC), and C3 (left motor cortex). STC distance and TMS electric fields were assessed at these EEG sites.

RESULTS: Individuals with AUD had significantly lower GMV in the bilateral orbitofrontal cortices, supramarginal gyri, and the left DLPFC (voxel-threshold p < 0.05, cluster-threshold p < 0.05) and within all 3 TMS target locations, F (1, 264) = 14.12, p = 0.0002. There was no significant difference in STC distance between the AUD and the healthy control group at any tested cortical location, F (3, 252) = 1.906, p = 0.129.

CONCLUSIONS: Individuals with AUD had significantly lower GMV in multiple areas of interest for TMS treatment; however, these volumetric reductions did not impact STC distance. Given previous studies that have shown TMS-evoked changes in cortical and subcortical activity to be dependent on GMV, these data suggest that individuals with AUD may require higher doses of TMS to sufficiently modulate the neural circuits of interest.

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Feb 2, 2022 4:09:00 PM

Comparative Efficacy and Acceptability of 3 Repetitive Transcranial Magnetic Stimulation Devices for Depression: A Meta-Analysis of Randomized, Sham-Controlled Trials

Source: Neuropsychobiology. 81(1):60-68, 2022.

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Feb 2, 2022 1:45:00 PM

Repetitive Transcranial Magnetic Stimulation (rTMS) as a Promising Treatment for Craving in Stimulant Drugs and Behavioral Addiction: A Meta-Analysis

Source: Journal of Clinical Medicine. 11(3) (no pagination), 2022. Article Number:
624.

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Feb 1, 2022 5:01:00 PM

Effects of Acceptance and Commitment Therapy and Repetitive Transcranial Magnetic Stimulation on Obsessive-Compulsive Disorder

Source: Frontiers in Psychiatry. 12 (no pagination), 2021. Article Number: 720518.

Date of Publication:
12 Jan 2022.

Authors:
Zou J.; Wu S.; Yuan X.; Hu Z.; Tang J.; Hu M.

Abstract

OBJECTIVE: This study aims to explore the difference of clinical efficacy and psychological flexibility of sertraline hydrochloride combined with acceptance and commitment therapy (ACT) or repeated transcranial magnetic stimulation (rTMS) in patients with obsessive-compulsive disorder (OCD).

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Feb 1, 2022 1:42:00 PM

rTMS Reduces Craving and Alcohol Use in Patients with Alcohol Use Disorder: Results of a Randomized, Sham-Controlled Clinical Trial

Source: Journal of Clinical Medicine. 11(4) (no pagination), 2022. Article Number:
951.

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Feb 1, 2022 10:31:00 AM

Efficacy of Transcranial Magnetic Stimulation for Reducing Suicidal Ideation in Depression: A Meta-Analysis

Source: Frontiers in Psychiatry. 12 (no pagination), 2022. Article Number: 764183.

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