Reorganization of Motor Cortex by Vagus Nerve Stimulation Requires Cholinergic Innervation.
Hulsey DR; Hays SA; Khodaparast N; Ruiz A; Das P; Rennaker RL 2nd; Kilgard MP.
Brain Stimulation. 9(2):174-81, 2016 Mar-Apr.
[Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S.] UI: 26822960
Vagus nerve stimulation (VNS) paired with forelimb training drives robust, specific reorganization of movement representations in the motor cortex. The mechanisms that underlie VNS-dependent enhancement of map plasticity are largely unknown. The cholinergic nucleus basalis (NB) is a critical substrate in cortical plasticity, and several studies suggest that VNS activates cholinergic circuitry.